1. Gene
  2. HMGN2 - high mobility group nucleosomal binding domain 2 Gene

HMGN2 - high mobility group nucleosomal binding domain 2 Gene

中文名称:高迁移率基团核小体结合域 2

种属: Homo sapiens

同用名: HMG17

基因 ID: 3151 | 基因类型: protein coding

关于 HMGN2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,472,440-26,476,642 (from NCBI)

This gene has 10 transcripts (splice variants), 126 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 279.3), lymph node (RPKM 141.8) and 25 other tissues.

功能概要

由该基因编码的蛋白质结合核小体 DNA 并与转录活性染色质相关。与类似的蛋白质 HMGN1 一起,编码的蛋白质可能有助于维持可转录基因周围的开放染色质配置。还发现该蛋白质对细菌、病毒和真菌具有抗菌活性。[RefSeq 提供,2014 年 10 月]

The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]

HMGN2 基因产物(1)

mRNA Protein Name
NM_005517.4 NP_005508.1 non-histone chromosomal protein HMG-17
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21044950 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
IMP: 通过突变表型推断
16204630 GOA
involved in killing of cells of another organism IMP
IMP: 通过突变表型推断
16204630 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16204630 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
16204630 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16204630 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HMGN2 蛋白结构

HMG14_17

HMG14_17: HMG14 and HMG17 (2 - 89)

  • 0
  • 90 a.a.
蛋白主名 其他名称

non-histone chromosomal protein HMG-17

high mobility group nucleosome-binding domain-containing protein 2

HMGN2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HMGN2 P05204 PARP2 Homo sapiens Q9UGN5
Anti Tag CoIP
33961781
种属内
HMGN2 P05204 TERF2 Homo sapiens Q15554
Pull Down
21044950
种属内
HMGN2 P05204 TERF2 Homo sapiens Q15554
BiFC
21044950
种属间: 跨种属相互作用 种属内: 同种属相互作用

HMGN2 抗体

目录号 产品名 应用 反应物种
HY-P83094 HMGN2 Antibody (YA2839) WB, IHC-P Human

关联疾病

疾病名称 别名
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus HMGN2 MGD MGI:96136
Bos taurus HMGN2 VGNC VGNC:50536
Rattus norvegicus HMGN2 RGD RGD:620649