2. Gene
  3. STAC - SH3 and cysteine rich domain Gene

STAC - SH3 and cysteine rich domain Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SH3 和富半胱氨酸的结构域

种属: Homo sapiens

同用名: STAC1

基因 ID: 6769 | 基因类型: protein coding

关于 STAC

Cytogenetic location: 3p22.3-p22.2 Genomic coordinates (GRCh38): 3:36,380,504-36,548,007 (from NCBI)

This gene has 8 transcripts (splice variants), 204 orthologues and 2 paralogues. Biased expression in prostate (RPKM 5.7), lung (RPKM 4.4) and 11 other tissues.

功能概要

预测启用跨膜转运蛋白结合活性。预计参与蛋白质定位到质膜的正向调节；电压门控钙通道活性的正调节；和骨骼肌收缩。预测作用于细胞对热的反应的上游或内部；肌肉收缩；和电压门控钙通道活动的调节。预测位于 T 管。预测为质膜细胞质侧的外在成分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable transmembrane transporter binding activity. Predicted to be involved in positive regulation of protein localization to plasma membrane; positive regulation of voltage-gated Calcium Channel activity; and skeletal muscle contraction. Predicted to act upstream of or within cellular response to heat; muscle contraction; and regulation of voltage-gated Calcium Channel activity. Predicted to be located in T-tubule. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

STAC 基因产物(2)

mRNA Protein Name
NM_001292049.2 NP_001278978.1 SH3 and cysteine-rich domain-containing protein isoform 2
NM_003149.3 NP_003140.1 SH3 and cysteine-rich domain-containing protein isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16260042 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STAC 蛋白结构

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (108 - 152)

SH3_1

SH3_1: SH3 domain (291 - 336)

SH3_2

SH3_2: Variant SH3 domain (349 - 400)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
蛋白主名 其他名称

SH3 and cysteine-rich domain-containing protein

SRC homology 3 and cysteine-rich domain-containing protein

STAC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
STAC Q99469 KIAA1958 Homo sapiens Q8N8K9
Y2H Prey Pooling
32296183
种属内
STAC Q99469 KIAA1958 Homo sapiens Q8N8K9
Y2H Array
32296183
种属内
STAC Q99469 NCKIPSD Homo sapiens Q9NZQ3-3
Y2H Prey Pooling
32296183
种属内
STAC Q99469 NCKIPSD Homo sapiens Q9NZQ3-3
Validated Y2H
32296183
种属内
STAC Q99469 NCKIPSD Homo sapiens Q9NZQ3-3
Y2H Array
32296183
种属内
STAC Q99469 STAT5B Homo sapiens P51692
Y2H Prey Pooling
32296183
种属内
STAC Q99469 STAT5B Homo sapiens P51692
Y2H Array
32296183
种属内
STAC Q99469 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
种属内
STAC Q99469 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
种属内
STAC Q99469 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
种属内
STAC Q99469 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
种属内
STAC Q99469 POU6F2 Homo sapiens P78424
Y2H Array
32296183
种属内
STAC Q99469 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
STAC Q99469 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
STAC Q99469 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
种属内
STAC Q99469 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
种属内
STAC Q99469 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
种属内
STAC Q99469 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
种属内
STAC Q99469 PAX5 Homo sapiens Q02548
Y2H Array
32296183
种属内
STAC Q99469 PAX5 Homo sapiens Q02548
Y2H Prey Pooling
32296183
种属内
STAC Q99469 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
STAC Q99469 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属内
STAC Q99469 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属内
STAC Q99469 YWHAE Homo sapiens P62258
Peptide Array
16260042
种属内
STAC Q99469 YWHAE Homo sapiens P62258
Anti Tag CoIP
33961781
种属内
STAC Q99469 YWHAE Homo sapiens P62258
Anti Bait CoIP
16260042
种属内
STAC Q99469 YWHAE Homo sapiens P62258
Anti Tag CoIP
28514442
种属内
STAC Q99469 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
种属内
STAC Q99469 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
种属内
STAC Q99469 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
种属内
STAC Q99469 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
种属内
STAC Q99469 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
种属内
STAC Q99469 PAX6 Homo sapiens P26367
Y2H Array
32296183
种属内
STAC Q99469 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
种属内
STAC Q99469 RNF208 Homo sapiens Q9H0X6
Y2H Array
32296183
种属内
STAC Q99469 RNF208 Homo sapiens Q9H0X6
Y2H Prey Pooling
32296183
种属内
STAC Q99469 RNF208 Homo sapiens Q9H0X6
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Exudative Vitreoretinopathy 6

EVR6

Vitreoretinopathy, Exudative 6

Vitreoretinopathy, Exudative, Type 6
Myopathy, Congenital, Bailey-Bloch

Native American Myopathy

Nam

MYPBB

Myopathy, Congenital, Baily-Bloch

Anti-Hmg-Coa Myopathy

Anti-Srp Myopathy

Autoimmune Necrotizing Myositis

Imnm

Immune Myopathy With Myocyte Necrosis

Immune-Mediated Necrotizing Myopathy

Myopathy, Congenital, With Myopathic Facies, Scoliosis, And Malignant Hyperthermia

Necrotizing Autoimmune Myopathy

Congenital Myopathy-Cleft Palate-Malignant Hyperthermia Syndrome

Congenital Myopathy With Cleft Palate And Malignant Hyperthermia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16558 Butein 99.95% 否
HY-114981 SRTCX1002 Activator / 否
HY-RS13863 STAC Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13864 STAC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13865 STAC3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus STAC RGD RGD:1305745
Bos taurus STAC VGNC VGNC:35350
Macaca mulatta STAC VGNC VGNC:77900
Canis familiaris STAC VGNC VGNC:46870
Mus musculus STAC MGD MGI:1201400
Felis catus STAC VGNC VGNC:65741
Others STAC NCBI
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