2. Gene
  3. ALPK2 - alpha kinase 2 Gene

ALPK2 - alpha kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：α激酶 2

种属: Homo sapiens

同用名: HAK

基因 ID: 115701 | 基因类型: protein coding

关于 ALPK2

Cytogenetic location: 18q21.31-q21.32 Genomic coordinates (GRCh38): 18:58,481,247-58,629,091 (from NCBI)

This gene has 6 transcripts (splice variants), 171 orthologues and 4 paralogues. Biased expression in heart (RPKM 9.8), lymph node (RPKM 2.0) and 4 other tissues.

功能概要

预测启用 ATP 绑定活动；蛋白丝氨酸激酶活性；和蛋白丝氨酸/苏氨酸激酶活性。涉及多个过程，包括心外膜形态发生；心脏发育；负调控参与心脏发育的 Wnt 信号通路。在基因表达调控的上游或内部发挥作用。与基底外侧质膜共定位。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Involved in several processes, including epicardium morphogenesis; heart development; and negative regulation of Wnt signaling pathway involved in heart development. Acts upstream of or within regulation of gene expression. Colocalizes with basolateral plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ALPK2 基因产物(1)

mRNA Protein Name
NM_052947.4 NP_443179.3 alpha-protein kinase 2
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cardiac muscle cell development IMP
IMP: 通过突变表型推断
29888752 GOA
involved in epicardium morphogenesis IMP
IMP: 通过突变表型推断
29888752 GOA
involved in establishment of cell polarity IMP
IMP: 通过突变表型推断
28668886 GOA
involved in heart morphogenesis IMP
IMP: 通过突变表型推断
29888752 GOA
involved in negative regulation of Wnt signaling pathway involved in heart development IMP
IMP: 通过突变表型推断
29888752 GOA
involved in regulation of apoptotic process IMP
IMP: 通过突变表型推断
22641666 GOA
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
22641666 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with basolateral plasma membrane IMP
IMP: 通过突变表型推断
28668886 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ALPK2 蛋白结构

I-set

I-set: Immunoglobulin I-set domain (15 - 104)

I-set

I-set: Immunoglobulin I-set domain (1803 - 1874)

Alpha_kinase

Alpha_kinase: Alpha-kinase family (1925 - 2125)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2170 a.a.
蛋白主名 其他名称

alpha-protein kinase 2

heart alpha-kinase

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00630 ALPK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ALPK2 VGNC VGNC:59760
Mus musculus ALPK2 MGD MGI:2449492
Rattus norvegicus ALPK2 RGD RGD:1564431
Bos taurus ALPK2 VGNC VGNC:25848
Canis familiaris ALPK2 VGNC VGNC:37816
Macaca mulatta ALPK2 VGNC VGNC:69648
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