Aldh2 - aldehyde dehydrogenase 2, mitochondrial Gene

中文名称：乙醛脱氢酶 2 ，线粒体

种属: Mus musculus

同用名: Ahd5; ALDHI; Ahd-5; AHD-M1; ALDH-E2

关于 Aldh2

功能概要

预测该基因编码的蛋白可启动 NADH 结合活性；醛脱氢酶 (NAD+) 活性；和相同的蛋白质结合活性。预计参与多个过程，包括对乙醇的行为反应；醛的细胞解毒；和响应氧化应激的内在凋亡信号通路。位于线粒体中。以多种结构表达，包括消化系统；泌尿生殖系统；神经系统;呼吸系统;和感觉器官。该基因的人类直系同源基因与多种疾病有关，包括酒精使用障碍；动脉疾病（多发性）；糖尿病（多发性）；糖尿病性神经病变；和肝病（多种）。与人类 ALDH2（醛脱氢酶 2 家族成员）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable NADH binding activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Predicted to be involved in several processes, including behavioral response to ethanol; cellular detoxification of aldehyde; and intrinsic apoptotic signaling pathway in response to oxidative stress. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Apr 2022]