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  3. Alox12 - arachidonate 12-lipoxygenase Gene

Alox12 - arachidonate 12-lipoxygenase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：花生四烯酸 12-脂氧合酶

种属: Mus musculus

同用名: P-12LO; Alox12p; 9930022G08Rik

基因 ID: 11684 | 基因类型: protein coding

关于 Alox12

Chromosome 11: 70,132,283-70,146,179 reverse strand.GRCm39:CM001004.3

This gene has 2 transcripts (splice variants), 198 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in genital fat pad adult (RPKM 9.9), spleen adult (RPKM 9.6) and 19 other tissues.

功能概要

该基因编码的蛋白可启动花生四烯酸 12(S)-脂氧合酶活性和亚油酸 13S-脂氧合酶活性。参与建立皮肤屏障；脂肪酸代谢过程；和血小板聚集的负调节。位于细胞质中。在消化系统中表达；肝;肝左叶；和肝右叶。与人类 ALOX12（花生四烯酸 12-脂氧合酶，12S 型）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables arachidonate 12(S)-lipoxygenase activity and linoleate 13S-lipoxygenase activity. Involved in establishment of skin barrier; fatty acid metabolic process; and negative regulation of platelet aggregation. Located in cytoplasm. Is expressed in alimentary system; liver; liver left lobe; and liver right lobe. Orthologous to human ALOX12 (arachidonate 12-lipoxygenase, 12S type). [provided by Alliance of Genome Resources, Apr 2022]

Alox12 基因产物(2)

mRNA Protein Name
NM_001331118.1 NP_001318047.1 polyunsaturated fatty acid lipoxygenase ALOX12 isoform 2
NM_007440.5 NP_031466.2 polyunsaturated fatty acid lipoxygenase ALOX12 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables arachidonate 12(S)-lipoxygenase activity IDA
IDA: 通过直接分析推断
8188678 MGI
enables arachidonate 12(S)-lipoxygenase activity IMP
IMP: 通过突变表型推断
11256953 MGI
enables linoleate 13S-lipoxygenase activity IMP
IMP: 通过突变表型推断
11256953 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in arachidonate metabolic process IDA
IDA: 通过直接分析推断
8188678 MGI
involved in arachidonate metabolic process IMP
IMP: 通过突变表型推断
9501222 MGI
involved in establishment of skin barrier IMP
IMP: 通过突变表型推断
10383730 MGI
involved in fatty acid oxidation IDA
IDA: 通过直接分析推断
25293588 MGI
involved in lipoxygenase pathway IDA
IDA: 通过直接分析推断
8188678 MGI
involved in lipoxygenase pathway IMP
IMP: 通过突变表型推断
9501222 MGI
involved in negative regulation of platelet aggregation IMP
IMP: 通过突变表型推断
9501222 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
7868854 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Alox12 蛋白结构

PLAT_LOX

PLAT_LOX: cd01753 (1 - 110)

Lipoxygenase

Lipoxygenase: cl37981 (220 - 653)

  • 0
  • 200
  • 400
  • 600
  • 663 a.a.
蛋白主名 其他名称

polyunsaturated fatty acid lipoxygenase ALOX12

12S-LOX

12S-lipoxygenase

arachidonate (12S)-lipoxygenase

arachidonate (15S)-lipoxygenase

arachidonate 12-lipoxygenase, 12S-type

arachidonate 15-lipoxygenase,15S-type

linoleate 13S-lipoxygenase

lipoxin synthase 12-LO

platelet-type lipoxygenase 12

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00612 ALOX12 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00613 Alox12 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00614 Alox12 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00615 ALOX12B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Alox12 NCBI NCBI:239
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