2. Gene
  3. Alox5 - arachidonate 5-lipoxygenase Gene

Alox5 - arachidonate 5-lipoxygenase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：花生四烯酸 5-脂氧合酶

种属: Mus musculus

同用名: 5LO; 5LX; 5-LO; 5-LOX; F730011J02

基因 ID: 11689 | 基因类型: protein coding

关于 Alox5

Chromosome 6: 116,387,038-116,438,139 reverse strand.GRCm39:CM000999.3

This gene has 8 transcripts (splice variants), 221 orthologues, 6 paralogues and is associated with 17 phenotypes. Broad expression in lung adult (RPKM 3.4), heart adult (RPKM 2.7) and 22 other tissues.

功能概要

该基因编码的蛋白可启动花生四烯酸 5-脂氧合酶活性。参与多个过程，包括白细胞迁移；血管生成的负调节；和调节细胞对压力的反应。在参与炎症反应的白三烯生物合成过程和白三烯生产的上游或内部起作用。位于细胞质和细胞核中。在十二指肠上皮和小肠上皮中表达。该基因的人类直系同源物与动脉疾病有关（多个）；哮喘（多发）；胰腺癌;和肺结核。与人类 ALOX5（花生四烯酸 5-脂氧合酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables arachidonate 5-lipoxygenase activity. Involved in several processes, including leukocyte migration; negative regulation of angiogenesis; and regulation of cellular response to stress. Acts upstream of or within leukotriene biosynthetic process and leukotriene production involved in inflammatory response. Located in cytoplasm and nucleus. Is expressed in duodenum epithelium and small intestine epithelium. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Alox5 基因产物(1)

mRNA Protein Name
NM_009662.2 NP_033792.1 polyunsaturated fatty acid 5-lipoxygenase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables arachidonate 5-lipoxygenase activity IDA
IDA: 通过直接分析推断
23246375 MGI
enables arachidonate 5-lipoxygenase activity IMP
IMP: 通过突变表型推断
31642348 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
19075240 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in dendritic cell migration IMP
IMP: 通过突变表型推断
17392829 MGI
involved in glucose homeostasis IMP
IMP: 通过突变表型推断
18421434 MGI
involved in humoral immune response IMP
IMP: 通过突变表型推断
21224059 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
11867678 MGI
involved in leukocyte migration involved in inflammatory response IMP
IMP: 通过突变表型推断
28965882 MGI
involved in leukotriene A4 biosynthetic process IMP
IMP: 通过突变表型推断
31642348 MGI
acts upstream of or within leukotriene biosynthetic process IDA
IDA: 通过直接分析推断
19075240 MGI
involved in leukotriene biosynthetic process IMP
IMP: 通过突变表型推断
7809134 MGI
acts upstream of or within leukotriene metabolic process IMP
IMP: 通过突变表型推断
11867678 MGI
acts upstream of or within leukotriene production involved in inflammatory response IMP
IMP: 通过突变表型推断
9091580 MGI
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
21307302 MGI
involved in negative regulation of endothelial cell proliferation IMP
IMP: 通过突变表型推断
21307302 MGI
involved in negative regulation of response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
28694473 MGI
involved in negative regulation of sprouting angiogenesis IMP
IMP: 通过突变表型推断
21307302 MGI
involved in negative regulation of vascular wound healing IMP
IMP: 通过突变表型推断
24226420 MGI
involved in negative regulation of wound healing IMP
IMP: 通过突变表型推断
24226420 MGI
involved in positive regulation of bone mineralization IMP
IMP: 通过突变表型推断
24906289 MGI
involved in positive regulation of leukocyte adhesion to arterial endothelial cell IMP
IMP: 通过突变表型推断
23720274 MGI
involved in regulation of cellular response to oxidative stress IMP
IMP: 通过突变表型推断
28694473 MGI
involved in regulation of cytokine production involved in inflammatory response IMP
IMP: 通过突变表型推断
28965882 MGI
involved in regulation of fat cell differentiation IMP
IMP: 通过突变表型推断
24906289 MGI
involved in regulation of inflammatory response IMP
IMP: 通过突变表型推断
7809134 MGI
involved in regulation of inflammatory response to wounding IMP
IMP: 通过突变表型推断
28965882 MGI
involved in regulation of insulin secretion IMP
IMP: 通过突变表型推断
18421434 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12140292 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12140292 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Alox5 蛋白结构

PLAT_LOX

PLAT_LOX: cd01753 (1 - 114)

Lipoxygenase

Lipoxygenase: cl37981 (220 - 664)

  • 0
  • 200
  • 400
  • 600
  • 674 a.a.
蛋白主名 其他名称

polyunsaturated fatty acid 5-lipoxygenase

5-lipoxygenase

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00620 ALOX5 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00621 Alox5 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00622 Alox5 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00623 ALOX5AP Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00624 Alox5ap Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00625 Alox5ap Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Alox5 NCBI NCBI:240
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