ARAP1 - ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Gene

中文名称：具有 RhoGAP 结构域、锚蛋白重复序列和 PH 结构域 1 的 ArfGAP

种属: Homo sapiens

同用名: CENTD2; cnt-d2

关于 ARAP1

功能概要

该基因编码的蛋白质包含 SAM、ARF-GAP、RHO-GAP、锚蛋白重复序列、RAS 相关和 pleckstrin 同源 (PH) 结构域。在体外，这种蛋白质表现出 RHO-GAP 和磷脂酰肌醇 (3,4,5) 三磷酸 (PIP3) 依赖性 ARF-GAP 活性。编码的蛋白质与高尔基体结合，ARF-GAP 活性介导高尔基体的变化和丝状伪足的形成。它被认为可以调节参与细胞凋亡的受体蛋白的细胞特异性运输。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 9 月]

The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in Apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]