THEM4 - thioesterase superfamily member 4 Gene

中文名称：硫酯酶超家族成员 4

种属: Homo sapiens

同用名: CTMP

基因 ID: 117145 | 基因类型: protein coding

关于 THEM4

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,870,866-151,909,511 (from NCBI)

This gene has 5 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 4.4), testis (RPKM 3.1) and 25 other tissues.

功能概要

蛋白激酶 B (PKB) 是通过磷脂酰肌醇 3-激酶发出信号的受体酪氨酸激酶的主要下游靶标。细胞刺激后，PKB 易位至质膜，在 C 末端调节域中被磷酸化。该基因编码的蛋白质通过抑制磷酸化来负向调节 PKB 活性。该基因的转录通常在胶质母细胞瘤中下调。[RefSeq 提供，2008 年 7 月]

Protein kinase B (PKB) is a major downstream target of Receptor Tyrosine Kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]

THEM4 基因产物(1)

mRNA	Protein	Name
NM_053055.5	NP_444283.2	acyl-coenzyme A thioesterase THEM4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables long-chain fatty acyl-CoA hydrolase activity	IDA IDA: 通过直接分析推断	22871024	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19541650	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in fatty acid metabolic process	IDA IDA: 通过直接分析推断	22871024	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: 通过突变表型推断	19168129	GOA
involved in regulation of mitochondrial membrane permeability involved in apoptotic process	IMP IMP: 通过突变表型推断	19168129	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	19604401	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	19604401	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

THEM4 蛋白结构

4HBT

0
100
200
240 a.a.

蛋白主名

其他名称

acyl-coenzyme A thioesterase THEM4

C-terminal modulator protein

THEM4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	THEM4	Q5T1C6	AKT1	Homo sapiens	P31749	Anti Bait CoIP	19541650
种属内	THEM4	Q5T1C6	AKT1	Homo sapiens	P31749	Anti Tag CoIP	19541650
种属内	THEM4	Q5T1C6	HRAS	Homo sapiens	P01112	Y2H Array	32814053
种属内	THEM4	Q5T1C6	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
种属内	THEM4	Q5T1C6	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
种属内	THEM4	Q5T1C6	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
种属内	THEM4	Q5T1C6	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
种属内	THEM4	Q5T1C6	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Erythrocytosis, Familial, 7

ECYT7	Erythrocytosis 7
Familial Erythrocytosis 7	Erythrocytosis, Alpha-Globin Type
Polycythemia, Alpha-Globin Type	Alpha-Globin Type Erythrocytosis
Alpha-Globin Type Polycythemia

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-W002004	4-Amino-tempo		99.60%	否
HY-RS14485	THEM4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	THEM4	VGNC	VGNC:78406
Felis catus	THEM4	VGNC	VGNC:66159
Rattus norvegicus	THEM4	RGD	RGD:1304723
Mus musculus	THEM4	MGD	MGI:1923028
Canis familiaris	THEM4	VGNC	VGNC:47341
Bos taurus	THEM4	VGNC	VGNC:35833

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

THEM4 - thioesterase superfamily member 4 Gene

关于 THEM4

功能概要

THEM4 基因产物(1)

THEM4 蛋白结构

THEM4 蛋白互作信息

关联疾病

直系同源

热门区域

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THEM4 - thioesterase superfamily member 4 Gene

关于 THEM4

功能概要

THEM4 基因产物(1)

THEM4 蛋白结构

THEM4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z