CLC - Charcot-Leyden crystal galectin Gene

中文名称：Charcot-Leyden 晶体半乳糖凝集素

种属: Homo sapiens

同用名: GAL10; Gal-10; LGALS10; LGALS10A; LPPL_HUMAN

基因 ID: 1178 | 基因类型: protein coding

关于 CLC

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,731,255-39,738,029 (from NCBI)

This gene has 1 transcript (splice variant), 330 orthologues and 16 paralogues. Biased expression in bone marrow (RPKM 112.7), urinary bladder (RPKM 16.5) and 5 other tissues.

功能概要

溶血磷脂酶是作用于生物膜以调节多功能溶血磷脂的酶。该基因编码的蛋白质是在嗜酸性粒细胞和嗜碱性粒细胞中表达的溶血磷脂酶。它将溶血磷脂酰胆碱水解为甘油磷酸胆碱和游离脂肪酸。这种蛋白质可能具有碳水化合物或 IgE 结合活性。它在结构和功能上都与 β-半乳糖苷结合蛋白的半乳糖凝集素家族相关。它可能与炎症和一些骨髓性白血病有关。[RefSeq 提供，2008 年 7 月]

Lysophospholipases are Enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the Galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]

CLC 基因产物(1)

mRNA	Protein	Name
NM_001828.6	NP_001819.2	galectin-10

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: 通过直接分析推断	17502455	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
NOT contributes to lysophospholipase activity	IDA IDA: 通过直接分析推断	11834744	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11834744	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in T cell apoptotic process	IDA IDA: 通过直接分析推断	17502455	GOA
involved in regulation of T cell anergy	IMP IMP: 通过突变表型推断	17502455	GOA
involved in regulation of T cell cytokine production	IMP IMP: 通过突变表型推断	17502455	GOA
involved in regulation of activated T cell proliferation	IMP IMP: 通过突变表型推断	17502455	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	17502455	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLC 蛋白结构

Gal-bind_lectin

0
100
142 a.a.

蛋白主名

其他名称

galectin-10

Charcot-Leyden crystal protein

CLC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CLC	Q05315	CLC	Homo sapiens	Q05315	Y2H Array	32296183
种属内	CLC	Q05315	CLC	Homo sapiens	Q05315	Validated Y2H	32296183
种属内	CLC	Q05315	CLC	Homo sapiens	Q05315	Y2H Prey Pooling	32296183
种属内	CLC	Q05315	CLC	Homo sapiens	Q05315	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CLC 蛋白

目录号	产品名	蛋白编号	纯度
HY-P700073AF	Animal-Free Galectin-10 Protein, Human (His)	Q05315 (S2-R142)	≥95%

关联疾病

疾病名称

别名

Allergic Rhinitis

Hay Fever	Allergic Rhinitis, Susceptibility To
ALRH	Atopic Rhinitis
Seasonal Allergic Rhinitis	Non-Seasonal Allergic Rhinitis
Perenial Allergic Rhinitis	Pollenosis
Rhinitis Allergic Seasonal	Rhinitis, Allergic, Perennial
Allergic Rhinitis, Cause Unspecified	Pollinosis
Pollen Allergy	Allergy Nos Due To Pollen
Summer Catarrh	Other Seasonal Allergic Rhinitis

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Galactosemia Iii

Galactose Epimerase Deficiency	Gale Deficiency
Udp-Galactose-4-Epimerase Deficiency	Epimerase Deficiency Galactosemia
Galactosemia Type 3	Gale-D
Uridine Diphosphate Galactose-4-Epimerase Deficiency	GALAC3
Galactosemia 3	Generalized Uridine Diphosphate Galactose-4-Epimerase Deficiency
Erythrocyte Uridine Diphosphate Galactose-4-Epimerase Deficiency	Galactosemia Type Iii
Udp-Galactose-4'-Epimerase Deficiency	Generalized Galactose Epimerase Deficiency
Generalized Gale Deficiency	Generalized Gale-D
Generalized Udp-Galactose-4-Epimerase Deficiency	Generalized Epimerase Deficiency Galactosemia
Erythrocyte Galactose Epimerase Deficiency	Erythrocyte Gale Deficiency
Erythrocyte Gale-D	Erythrocyte Udp-Galactose-4-Epimerase Deficiency
Erythrocyte Epimerase Deficiency Galactosemia	Galactosemias
Classical Galactosemia	Udpglucose 4-Epimerase Deficiency Disease

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis	EOE1
Esophagitis, Eosinophilic	Ee

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-112496	Cl-C6-PEG4-O-CH2COOH		≥98.0%	否
HY-135306	Cl-C6-PEG4-C3-COOH		99.65%	否
HY-158183	NMD670	Inhibitor	99.60%	否
HY-P1105	GaTx2		98.40%	否
HY-RS02747	CLC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W414069	Thiocholesterol		/	否
HY-122732	OADS	Inhibitor	/	否

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CLC - Charcot-Leyden crystal galectin Gene

关于 CLC

功能概要

CLC 基因产物(1)

CLC 蛋白结构

CLC 蛋白互作信息

重组 CLC 蛋白

关联疾病

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CLC - Charcot-Leyden crystal galectin Gene

关于 CLC

功能概要

CLC 基因产物(1)

CLC 蛋白结构

CLC 蛋白互作信息

重组 CLC 蛋白

关联疾病

相关产品

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z