2. Gene
  3. MMP21 - matrix metallopeptidase 21 Gene

MMP21 - matrix metallopeptidase 21 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：基质金属肽酶 21

种属: Homo sapiens

同用名: HTX7; MMP-21

基因 ID: 118856 | 基因类型: protein coding

关于 MMP21

Cytogenetic location: 10q26.2 Genomic coordinates (GRCh38): 10:125,766,453-125,775,821 (from NCBI)

This gene has 4 transcripts (splice variants), 156 orthologues, 23 paralogues and is associated with 4 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码基质金属蛋白酶家族的一个成员。该家族中的蛋白质参与正常生理过程 (如胚胎发育、繁殖和组织重塑) 和疾病过程 (如哮喘和肿瘤转移) 的细胞外基质分解。编码的蛋白质可能在胚胎发生中发挥重要作用，特别是在神经元细胞中，以及在淋巴细胞发育和存活中。[RefSeq 提供，2013 年 5 月]

This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013]

MMP21 基因产物(1)

mRNA Protein Name
NM_147191.1 NP_671724.1 matrix metalloproteinase-21 preproprotein
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in determination of left/right symmetry IMP
IMP: 通过突变表型推断
26429889 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MMP21 蛋白结构

PG_binding_1

PG_binding_1: Putative peptidoglycan binding domain (48 - 112)

Peptidase_M10

Peptidase_M10: Matrixin (172 - 327)

Hemopexin

Hemopexin: Hemopexin (356 - 390)

Hemopexin

Hemopexin: Hemopexin (403 - 449)

Hemopexin

Hemopexin: Hemopexin (452 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 569 a.a.
蛋白主名 其他名称

matrix metalloproteinase-21

matrix metalloproteinase 21

关联疾病

疾病名称 别名
Heterotaxy, Visceral, 7, Autosomal

HTX7

Heterotaxy, Visceral, Autosomal, Type 7
Dextrocardia With Situs Inversus

Situs Inversus Totalis

Complete Situs Inversus

Complete Situs Inversus Viscerum

Situs Inversus
Visceral Heterotaxy

Situs Ambiguus

Heterotaxia

Heterotaxy Syndrome

Heterotaxy

Lateralization Defect

Situs Ambiguous

Left Isomerism

Htx

Ivemark Syndrome

Right Isomerism

Situs Ambiguus Viscerum

Incomplete Situs Inversus

Partial Situs Inversus

Heterotaxy, Visceral

Asplenia Syndrome

Bilateral Left-Sidedness

Polysplenia Syndrome

Moller Syndrome
Borna Disease

Enzootic Encephalomyelitis
Phonagnosia
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08541 MMP21 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MMP21 VGNC VGNC:63537
Mus musculus MMP21 MGD MGI:2664387
Macaca mulatta MMP21 VGNC VGNC:74754
Canis familiaris MMP21 VGNC VGNC:43282
Rattus norvegicus MMP21 RGD RGD:1309332
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