2. Gene
  3. Bmpr1b - bone morphogenetic protein receptor, type 1B Gene

Bmpr1b - bone morphogenetic protein receptor, type 1B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：骨形态发生蛋白受体，1B 型

种属: Mus musculus

同用名: Alk6; SKR6; ALK-6; Acvrlk6; BMPR-1B; BMPR-IB; CFK-43a

基因 ID: 12167 | 基因类型: protein coding

关于 Bmpr1b

Chromosome 3: 141,542,897-141,875,186 reverse strand.GRCm39:CM000996.3

This gene has 5 transcripts (splice variants), 290 orthologues, 11 paralogues and is associated with 39 phenotypes. Biased expression in limb E14.5 (RPKM 1.8), frontal lobe adult (RPKM 1.8) and 11 other tissues.

功能概要

该基因编码一种丝氨酸/苏氨酸激酶，作为骨形态发生蛋白 (BMP) 的受体发挥作用。编码的蛋白质是 I 型受体，在细胞膜上形成两个 II 型和两个 I 型受体的复合物。该复合物向下游发出信号以激活 SMAD 转录调节因子。这种信号在骨骼和骨骼发育中很重要。可变剪接导致多个转录本变体。 [RefSeq 提供，2013 年 3 月]

This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type I receptor, and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important in skeletal and bone development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Bmpr1b 基因产物(6)

mRNA Protein Name
NM_001277217.3 NP_001264146.1 bone morphogenetic protein receptor type-1B isoform a precursor
NM_001277220.2 NP_001264149.1 bone morphogenetic protein receptor type-1B isoform b
NM_007560.5 NP_031586.1 bone morphogenetic protein receptor type-1B isoform a precursor
NM_001277216.3 NP_001264145.1 bone morphogenetic protein receptor type-1B isoform a precursor
NM_001355043.2 NP_001341972.1 bone morphogenetic protein receptor type-1B isoform a precursor
NM_001277218.2 NP_001264147.1 bone morphogenetic protein receptor type-1B isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables BMP binding IDA
IDA: 通过直接分析推断
11714695 MGI
enables BMP receptor activity IDA
IDA: 通过直接分析推断
11714695 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15239668 MGI
enables transforming growth factor beta receptor activity, type I IMP
IMP: 通过突变表型推断
11376112 MGI
enables transmembrane receptor protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
14523231 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in BMP signaling pathway IDA
IDA: 通过直接分析推断
11714695 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
16049014 MGI
acts upstream of or within BMP signaling pathway IMP
IMP: 通过突变表型推断
11376112 MGI
involved in bone development IMP
IMP: 通过突变表型推断
20551513 MGI
acts upstream of or within camera-type eye development IGI
IGI: 通过遗传相互作用推断
15673568 MGI
acts upstream of or within cartilage condensation IMP
IMP: 通过突变表型推断
10631181 MGI
acts upstream of or within cell differentiation IMP
IMP: 通过突变表型推断
12117821 MGI
acts upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway IGI
IGI: 通过遗传相互作用推断
18363966 MGI
involved in cellular response to growth factor stimulus IDA
IDA: 通过直接分析推断
24129431 MGI
acts upstream of or within central nervous system neuron differentiation IGI
IGI: 通过遗传相互作用推断
15469980 MGI
acts upstream of or within chondrocyte differentiation IGI
IGI: 通过遗传相互作用推断
18363966 MGI
involved in chondrocyte differentiation IMP
IMP: 通过突变表型推断
24098149 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: 通过遗传相互作用推断
15673568 MGI
acts upstream of or within eye development IMP
IMP: 通过突变表型推断
12117821 MGI
involved in inflammatory response IEP
IEP: 通过表达模式推断
12151307 MGI
involved in osteoblast differentiation IDA
IDA: 通过直接分析推断
20551513 MGI
involved in ovarian cumulus expansion IMP
IMP: 通过突变表型推断
11416163 MGI
involved in ovulation cycle IMP
IMP: 通过突变表型推断
11416163 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
IGI: 通过遗传相互作用推断
18363966 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: 通过突变表型推断
12654290 MGI
acts upstream of or within retinal ganglion cell axon guidance IMP
IMP: 通过突变表型推断
12654290 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
24129431 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Bmpr1b 蛋白结构

Activin_recp

Activin_recp: pfam01064 (29 - 105)

STKc_BMPR1b

STKc_BMPR1b: cd14219 (197 - 501)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 502 a.a.
蛋白主名 其他名称

bone morphogenetic protein receptor type-1B

BMP type-1B receptor

activin receptor-like kinase 6

serine/threonine-protein kinase receptor R6

重组 Bmpr1b 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76176 BMPRIB/ALK-6 Protein, Mouse (HEK293, Fc) P36898 (K14-K126) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01549 BMPR1B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01550 Bmpr1b Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01551 Bmpr1b Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bmpr1b NCBI NCBI:658
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