PSMB11 - proteasome subunit beta 11 Gene

中文名称：蛋白酶体亚基 11

种属: Homo sapiens

同用名: BETA5T

关于 PSMB11

功能概要

蛋白酶体产生由主要组织相容性复合体 (MHC) I 分子呈递给免疫系统其他细胞的肽。蛋白水解由 20S 蛋白酶体进行，28 个亚基的复合物排列成 4 个异七聚体环中的圆柱体：alpha-1 到 -7、beta-1 到 -7、beta-1 到 -7 和 alpha-1 到 -7。催化亚基是 beta-1 (PSMB6；MIM 600307) 、beta-2 (PSMB7；MIM 604030) 和 beta-5 (PSMB5；MIM 600306) 。三个额外的亚基，beta-1i (PSMB9；MIM 177045) 、beta-2i (PSMB10；MIM 176847) 和 beta-5i (PSMB8；MIM 177046) ，由γ-干扰素 (IFNG；MIM 147570) 诱导并优先并入蛋白酶体以形成免疫蛋白酶体。 PSMB11 或 beta-5t 是一种只在皮质胸腺上皮细胞中表达的催化亚基 (Murata 等人，2007 [PubMed 17540904]) 。[OMIM 提供，2008 年 3 月]

Proteasomes generate Peptides that are presented by major histocompatibility complex (MHC) I molecules to Other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008]