Casp2 - caspase 2 Gene

中文名称：半胱天冬酶 2

种属: Mus musculus

同用名: ICH-1; Nedd2; CASP-2; NEDD-2

关于 Casp2

功能概要

该基因编码进化上最古老和最保守的半胱氨酸蛋白酶成员，在应激诱导的细胞凋亡、DNA 修复和肿瘤抑制中起重要作用。缺乏编码蛋白的小鼠发育正常，但显示细胞类型特异性凋亡缺陷。发现来自这些小鼠的生殖细胞和卵母细胞在用化疗药物治疗后对细胞死亡有抵抗力。 [RefSeq 提供，2015 年 4 月]

This gene encodes the evolutionarily ancient and most conserved member of the cysteine proteases that plays important role in stress-induced Apoptosis, DNA repair and tumor suppression. Mice lacking the encoded protein develop normally but display cell type-specific apoptotic defects. Germ cells and oocytes from such mice were found to be resistant to cell death after treatment with chemotherapeutic drugs. [provided by RefSeq, Apr 2015]