2. Gene
  3. WFIKKN2 - WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 Gene

WFIKKN2 - WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 WAP、follistatin/kazal、免疫球蛋白、kunitz 和 netrin 结构域 2

种属: Homo sapiens

同用名: GASP-1; WFDC20B; hGASP-1; WFIKKNRP

基因 ID: 124857 | 基因类型: protein coding

关于 WFIKKN2

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,834,584-50,842,353 (from NCBI)

This gene has 2 transcripts (splice variants), 148 orthologues and 13 paralogues. Biased expression in ovary (RPKM 30.8) and testis (RPKM 1.8).

功能概要

WFIKKN1 蛋白包含一个 WAP 结构域、卵泡抑素结构域、免疫球蛋白结构域、两个串联 Kunitz 结构域和一个 NTR 结构域。该基因编码 WFIKKN1 相关蛋白，该蛋白具有与 WFIKKN1 蛋白相同的结构域结构。 WAP 型、follistatin 型、Kunitz 型和 NTR 型蛋白酶抑制结构域可能控制多种蛋白酶的作用。[RefSeq 提供，2008 年 7 月]

The WFIKKN1 protein contains a WAP domain, Follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, Follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]

WFIKKN2 基因产物(2)

mRNA Protein Name
NM_001330341.2 NP_001317270.1 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform 2
NM_175575.6 NP_783165.1 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18596030 GOA
enables receptor antagonist activity IDA
IDA: 通过直接分析推断
21054789 GOA
enables transforming growth factor beta binding IDA
IDA: 通过直接分析推断
21054789 GOA
enables transforming growth factor beta binding IPI
IPI: 通过物理相互作用推断
12595574 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
21054789 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
12595574 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WFIKKN2 蛋白结构

WAP

WAP: WAP-type (Whey Acidic Protein) 'four-disulfide core' (42 - 90)

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (138 - 168)

I-set

I-set: Immunoglobulin I-set domain (213 - 304)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (328 - 379)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (385 - 436)

NTR

NTR: UNC-6/NTR/C345C module (457 - 559)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 576 a.a.
蛋白主名 其他名称

WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

WAP four-disulfide core domain 20B

重组 WFIKKN2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75173 GASP-1/WFIKKN2 Protein, Human (HEK293, His) Q8TEU8 (L35-H576) ≥95%

关联疾病

疾病名称 别名
Space Motion Sickness
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15812 WFIKKN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus WFIKKN2 MGD MGI:2669209
Bos taurus WFIKKN2 VGNC VGNC:55888
Canis familiaris WFIKKN2 VGNC VGNC:104174
Felis catus WFIKKN2 VGNC VGNC:99574
Macaca mulatta WFIKKN2 VGNC VGNC:79900
Rattus norvegicus WFIKKN2 RGD RGD:1305361
Others WFIKKN2 NCBI
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