2. Gene
  3. SPACA3 - sperm acrosome associated 3 Gene

SPACA3 - sperm acrosome associated 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：精子顶体相关 3

种属: Homo sapiens

同用名: CT54; LYC3; LYZC; LYZL3; SLLP1; ALLP17

基因 ID: 124912 | 基因类型: protein coding

关于 SPACA3

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:32,991,847-32,997,877 (from NCBI)

This gene has 5 transcripts (splice variants), 121 orthologues and 8 paralogues. Restricted expression toward testis (RPKM 20.0).

功能概要

该基因编码的蛋白质是一种精子表面蛋白，可能参与受精前与卵子的粘附。虽然编码的蛋白质在氨基酸水平上与溶菌酶有显着相似性，但它没有可检测的杀菌活性。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is a sperm surface protein that may be involved in adhesion to the egg prior to fertilization. While the encoded protein has significant similarity to lysozyme at the amino acid level, it has no detectable bacteriocidal activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

SPACA3 基因产物(3)

mRNA Protein Name
NM_001317225.2 NP_001304154.1 sperm acrosome membrane-associated protein 3 isoform 3
NM_001317226.2 NP_001304155.1 sperm acrosome membrane-associated protein 3 isoform 2
NM_173847.5 NP_776246.1 sperm acrosome membrane-associated protein 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables lysozyme activity IDA
IDA: 通过直接分析推断
12606493 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19945174 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in fusion of sperm to egg plasma membrane involved in single fertilization IMP
IMP: 通过突变表型推断
15982649 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in acrosomal matrix IDA
IDA: 通过直接分析推断
12606493 GOA
located in acrosomal membrane IDA
IDA: 通过直接分析推断
12606493 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPACA3 蛋白结构

Lys

Lys: C-type lysozyme/alpha-lactalbumin family (89 - 213)

  • 0
  • 100
  • 200
  • 215 a.a.
蛋白主名 其他名称

sperm acrosome membrane-associated protein 3

cancer/testis antigen 54

关联疾病

疾病名称 别名
Immunoglobulin Heavy-And-Light Chain

Ah/Al Amyloidosis

Ig Heavy-And-Light-Chain Amyloidosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13616 SPACA3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SPACA3 MGD MGI:1922872
Bos taurus SPACA3 VGNC VGNC:55872
Rattus norvegicus SPACA3 RGD RGD:1306684
Macaca mulatta SPACA3 VGNC VGNC:77930
Canis familiaris SPACA3 VGNC VGNC:46693
Felis catus SPACA3 VGNC VGNC:65591
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