OSCAR - osteoclast associated Ig-like receptor Gene

中文名称：破骨细胞相关 Ig 样受体

种属: Homo sapiens

同用名: PIGR3; PIgR-3

关于 OSCAR

功能概要

破骨细胞是吸收骨的多核细胞，对骨稳态至关重要。该基因编码破骨细胞相关受体 (OSCAR) ，它是白细胞受体复合蛋白家族的成员，在先天性和适应性免疫反应的调节中起着关键作用。编码的蛋白质可能在氧化应激介导的动脉粥样硬化形成和单核细胞粘附中发挥作用。已为该基因发现编码不同亚型的多个可变剪接转录物变体。[RefSeq 提供，2013 年 8 月]

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]