2. Gene
  3. Chek1 - checkpoint kinase 1 Gene

Chek1 - checkpoint kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：检查点激酶 1

种属: Mus musculus

同用名: Chk1; rad27

基因 ID: 12649 | 基因类型: protein coding

关于 Chek1

Chromosome 9: 36,619,778-36,638,361 reverse strand.GRCm39:CM001002.3

This gene has 8 transcripts (splice variants), 178 orthologues and is associated with 10 phenotypes. Biased expression in CNS E11.5 (RPKM 8.), liver E14 (RPKM 5.6) and 9 other tissues.

功能概要

该基因编码的蛋白可启动组蛋白激酶活性（H3-T11 特异性）。参与染色质转录能力构象的表观遗传维持；组蛋白 H3-K9 乙酰化的调控；以及响应紫外线诱导的 DNA 损伤而调节 RNA 聚合酶 II 启动子的转录。作用于多个过程的上游或内部，包括 DNA 损伤检查点信号；有丝分裂细胞周期的G2/M转换；和内细胞团细胞增殖。位于染色质；核;和复制叉。以多种结构表达，包括肾上腺髓质；早孕;性腺;直觉;和来自神经嵴的躯干间充质。该基因的人类直系同源物与胰腺癌有关。与人类 CHEK1（检查点激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables histone kinase activity (H3-T11 specific). Involved in epigenetic maintenance of chromatin in transcription-competent conformation; regulation of histone H3-K9 acetylation; and regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage. Acts upstream of or within several processes, including DNA damage checkpoint signaling; G2/M transition of mitotic cell cycle; and inner cell mass cell proliferation. Located in chromatin; nucleus; and replication fork. Is expressed in several structures, including adrenal medulla; early conceptus; gonad; gut; and trunk mesenchyme derived from neural crest. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human CHEK1 (checkpoint kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Chek1 基因产物(4)

mRNA Protein Name
NM_001410206.1 NP_001397135.1 serine/threonine-protein kinase Chk1 isoform 3
NM_001410205.1 NP_001397134.1 serine/threonine-protein kinase Chk1 isoform 2
NM_007691.6 NP_031717.2 serine/threonine-protein kinase Chk1 isoform 1
NM_001410207.1 NP_001397136.1 serine/threonine-protein kinase Chk1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone H3T11 kinase activity IDA
IDA: 通过直接分析推断
18243098 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15364958 MGI
enables protein kinase activity IMP
IMP: 通过突变表型推断
15364958 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage checkpoint signaling IDA
IDA: 通过直接分析推断
12529385 MGI
acts upstream of or within DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
10859164 MGI
acts upstream of or within DNA damage response IDA
IDA: 通过直接分析推断
11790307 MGI
involved in DNA damage response IMP
IMP: 通过突变表型推断
18243098 MGI
acts upstream of or within DNA repair IDA
IDA: 通过直接分析推断
15364958 MGI
acts upstream of or within G2/M transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
10859164 MGI
acts upstream of or within apoptotic process involved in development IMP
IMP: 通过突变表型推断
10859163 MGI
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
18243098 MGI
acts upstream of or within inner cell mass cell proliferation IMP
IMP: 通过突变表型推断
10859163 MGI
acts upstream of or within mitotic cell cycle checkpoint signaling IMP
IMP: 通过突变表型推断
10859163 MGI
involved in negative regulation of gene expression, epigenetic IMP
IMP: 通过突变表型推断
18243098 MGI
acts upstream of or within nucleus organization IMP
IMP: 通过突变表型推断
10859163 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
15364958 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: 通过突变表型推断
21737879 MGI
acts upstream of or within regulation of gene expression IGI
IGI: 通过遗传相互作用推断
21737879 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
18243098 MGI
located in nucleus IDA
IDA: 通过直接分析推断
11555636 MGI
located in replication fork IDA
IDA: 通过直接分析推断
15364958 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Chek1 蛋白结构

STKc_Chk1

STKc_Chk1: cd14069 (6 - 264)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase Chk1

CHK1 checkpoint homolog

checkpoint kinase 1 homolog

rad27 homolog

重组 Chek1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74253 Chk1 Protein, Mouse (sf9, His-GST) O35280 (M1-T476) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148065 FMF-06-098-1 / 否
HY-RS02616 CHEK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02617 Chek1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02618 Chek1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Chek1 NCBI NCBI:1111
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z