CNTFR - ciliary neurotrophic factor receptor Gene

中文名称：睫状神经营养因子受体

种属: Homo sapiens

基因 ID: 1271 | 基因类型: protein coding

关于 CNTFR

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,551,433-34,590,852 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 23 paralogues. Biased expression in fat (RPKM 23.5), brain (RPKM 9.3) and 10 other tissues.

功能概要

该基因编码 1 型细胞因子受体家族的成员。编码的蛋白质是睫状神经营养因子三联受体的配体特异性成分，在神经元细胞存活、分化和基因表达中起着关键作用。睫状神经营养因子与编码蛋白的结合募集受体 gp130 和白血病抑制因子受体的跨膜成分，促进信号转导。该基因中的单核苷酸多态性可能与肌肉力量的变化以及进食障碍的早期发作有关。已观察到该基因的可变剪接转录物变体。[RefSeq 提供，2011 年 5 月]

This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and Leukemia Inhibitory Factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

CNTFR 基因产物(3)

mRNA	Protein	Name
NM_001207011.2	NP_001193940.1	ciliary neurotrophic factor receptor subunit alpha preproprotein
NM_001842.5	NP_001833.1	ciliary neurotrophic factor receptor subunit alpha preproprotein
NM_147164.3	NP_671693.1	ciliary neurotrophic factor receptor subunit alpha preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to ciliary neurotrophic factor receptor activity	IDA IDA: 通过直接分析推断	12643274	GOA
enables cytokine binding	IPI IPI: 通过物理相互作用推断	15272019	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18775332	GOA
enables signaling receptor binding	IPI IPI: 通过物理相互作用推断	12707266	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ciliary neurotrophic factor-mediated signaling pathway	IDA IDA: 通过直接分析推断	12643274	GOA
involved in negative regulation of neuron apoptotic process	IMP IMP: 通过突变表型推断	19386761	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CNTFR-CLCF1 complex	IDA IDA: 通过直接分析推断	11285233	GOA
located in apical plasma membrane	IDA IDA: 通过直接分析推断	21912637	GOA
part of ciliary neurotrophic factor receptor complex	IDA IDA: 通过直接分析推断	12643274	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CNTFR 蛋白结构

fn3

0
100
200
300
372 a.a.

蛋白主名

其他名称

ciliary neurotrophic factor receptor subunit alpha

CNTF receptor subunit alpha

CNTFR 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CNTFR	P26992	CNTF	Homo sapiens	P26441	ITC	18775332
种属内	CNTFR	P26992	CNTF	Homo sapiens	P26441	GMS	18775332
种属内	CNTFR	P26992	SORL1	Homo sapiens	Q92673	Confocal	26858303
种属内	CNTFR	P26992	SORL1	Homo sapiens	Q92673	Crosslink	26858303
种属内	CNTFR	P26992	SORL1	Homo sapiens	Q92673	Anti Tag CoIP	26858303
种属内	CNTFR	P26992	SORL1	Homo sapiens	Q92673	SPR	26858303
种属内	CNTFR	P26992	SORL1	Homo sapiens	Q92673	Anti Bait CoIP	26858303
种属内	CNTFR	P26992	Q9UBD9-PRO_0000015616	Homo sapiens	Q9UBD9-PRO_0000015616	SPR	26858303
种属内	CNTFR	P26992	Q9UBD9-PRO_0000015616	Homo sapiens	Q9UBD9-PRO_0000015616	Confocal	26858303

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CNTFR 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76275	CNTFR alpha Protein, Human (sf9, His)	P26992 (Q23-P346)	≥95%

关联疾病

疾病名称

别名

Cold-Induced Sweating Syndrome

Crisponi Syndrome	Sohar-Crisponi Syndrome
Ciss	Cntf Receptor-Related Disorders
Muscle Contractions, Tetanoform, With Characteristic Face, Camptodactyly, Hyperthermia, And Sudden Death	Sweating Syndrome, Cold-Induced

Crisponi/Cold-Induced Sweating Syndrome 1

Crisponi Syndrome	Cold-Induced Sweating Syndrome 1
CISS1	Sohar-Crisponi Syndrome
Muscle Contractions, Tetanoform, With Characteristic Face, Camptodactyly, Hyperthermia, And Sudden Death	Muscle Contractions Tetanoform With Characteristic Face Camptodactyly Hyperthermia And Sudden Death

Crisponi/Cold-Induced Sweating Syndrome 2

Cold-Induced Sweating Syndrome 2	CISS2
Sweating Syndrome, Cold-Induced, Type 2

Hyper Ige Recurrent Infection Syndrome 4

Developmental And Epileptic Encephalopathy 11

Epileptic Encephalopathy, Early Infantile, 11	DEE11
Eiee11	Developmental And Epileptic Encephalopathy, 11
Early Infantile Epileptic Encephalopathy 11	Encephalopathy, Developmental And Epileptic, Type 11

Postsurgical Hypothyroidism

Postoperative Hypothyroidism

Post-Surgical Hypothyroidism

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02924	CNTFR Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CNTFR	VGNC	VGNC:39430
Felis catus	CNTFR	VGNC	VGNC:61035
Macaca mulatta	CNTFR	VGNC	VGNC:71282
Rattus norvegicus	CNTFR	RGD	RGD:1303100
Mus musculus	CNTFR	MGD	MGI:99605
Bos taurus	CNTFR	VGNC	VGNC:27535
Others	CNTFR	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CNTFR - ciliary neurotrophic factor receptor Gene

关于 CNTFR

功能概要

CNTFR 基因产物(3)

CNTFR 蛋白结构

CNTFR 蛋白互作信息

重组 CNTFR 蛋白

关联疾病

直系同源

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CNTFR - ciliary neurotrophic factor receptor Gene

关于 CNTFR

功能概要

CNTFR 基因产物(3)

CNTFR 蛋白结构

CNTFR 蛋白互作信息

重组 CNTFR 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z