2. Gene
  3. ADH7 - alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Gene

ADH7 - alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：乙醇脱氢酶 7 (IV 类) ，mu 或 sigma 多肽

种属: Homo sapiens

同用名: ADH4

基因 ID: 131 | 基因类型: protein coding

关于 ADH7

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,412,263-99,435,342 (from NCBI)

This gene has 6 transcripts (splice variants), 350 orthologues and 17 paralogues. Restricted expression toward esophagus (RPKM 95.5).

功能概要

该基因编码 IV 类乙醇脱氢酶 7 μ 或 sigma 亚基，是乙醇脱氢酶家族的一员。该家族的成员代谢多种底物，包括乙醇、视黄醇、其他脂肪醇、羟基类固醇和脂质过氧化产物。该基因编码的酶在乙醇氧化中效率低下，但作为视黄醇脱氢酶最为活跃；因此它可能参与视黄酸的合成，视黄酸是一种对细胞分化很重要的激素。该基因在胃中的表达比在肝脏中丰富得多，因此不同于其他已知的基因家族成员。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 10 月]

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, Other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The Enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the Other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

ADH7 基因产物(2)

mRNA Protein Name
NM_000673.7 NP_000664.3 all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform 2
NM_001166504.2 NP_001159976.1 all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables alcohol dehydrogenase (NAD+) activity IDA
IDA: 通过直接分析推断
7876099 GOA
enables aldehyde oxidase activity IDA
IDA: 通过直接分析推断
9600267 GOA
enables all-trans-retinol dehydrogenase (NAD+) activity IDA
IDA: 通过直接分析推断
7876099 GOA
enables ethanol binding IDA
IDA: 通过直接分析推断
9228021 GOA
enables receptor antagonist activity IDA
IDA: 通过直接分析推断
9600267 GOA
enables retinol binding IDA
IDA: 通过直接分析推断
9228021 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in fatty acid omega-oxidation IDA
IDA: 通过直接分析推断
9600267 GOA
involved in response to bacterium IDA
IDA: 通过直接分析推断
11410738 GOA
involved in response to ethanol IDA
IDA: 通过直接分析推断
9600267 GOA
involved in retinoid metabolic process IDA
IDA: 通过直接分析推断
9600267 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADH7 蛋白结构

ADH_N

ADH_N: Alcohol dehydrogenase GroES-like domain (47 - 172)

ADH_zinc_N

ADH_zinc_N: Zinc-binding dehydrogenase (214 - 343)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
蛋白主名 其他名称

all-trans-retinol dehydrogenase [NAD(+)] ADH7

alcohol dehydrogenase VII

重组 ADH7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7473 ADH7 Protein, Human (HEK293, His) P40394 (M1-F386) ≥95%

关联疾病

疾病名称 别名
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Atrophic Gastritis

Gastritis, Atrophic

Gastric Atrophy

Gastritis Atrophic
Gastritis

Acute Gastric Mucosal Erosion

Erosive Gastritis

Erosive Gastropathy

Gastritis Erosive

Idiopathic Erosive/Hemorrhagic Gastritis

Inflammation Of Gastric Mucosa

Gastroduodenitis

Gastritis Nos

Noninfectious Gastroenteritis

Nonbacterial Gastroenteritis Of Infant

Acute Gastric Infection

Acute Simple Gastritis

Chronic Antral Gastritis

Chronic Fundal Gastritis

Chronic Simple Gastritis

Acute Gastroduodenitis

Acute Antral Gastritis

Acute Erosive Gastritis

Bile Reflux Gastritis

Gastritis Due To Biliary Reflux
Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders

Arbd

Arnd

Alcohol-Related Birth Defects

Alcohol-Related Neurodevelopmental Disorder

Fas

Fasd

Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk

Alcohol Related Birth Defect

Alcohol Related Neurodevelopmental Disorder

Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk

Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk

Dysmorphism Due To Alcohol

Fetal Etoh Syndrome
Alcoholic Cardiomyopathy

Cardiomyopathy, Alcoholic

Alcohol-Induced Heart Muscle Disease

Dilated Cardiomyopathy Secondary To Alcohol
Substance Dependence
Fetal Alcohol Spectrum Disorder

Fetal Alcohol Spectrum Disorders

Fetal Alcohol Syndrome
Alcohol Use Disorder

Alcohol Abuse

Alcoholism

Ethanol Abuse

Alcohol Addiction

Alcohol Dependence

Alcoholic Intoxication, Chronic

Alcohol-Related Disorders
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00374 ADH7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ADH7 RGD RGD:621638
Mus musculus ADH7 MGD MGI:87926
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