2. Gene
  3. CD200R1 - CD200 receptor 1 Gene

CD200R1 - CD200 receptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CD200 受体 1

种属: Homo sapiens

同用名: OX2R; MOX2R; CD200R; HCRTR2

基因 ID: 131450 | 基因类型: protein coding

关于 CD200R1

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:112,921,205-112,975,103 (from NCBI)

This gene has 5 transcripts (splice variants), 235 orthologues and 1 paralogue. Broad expression in spleen (RPKM 4.6), placenta (RPKM 2.9) and 22 other tissues.

功能概要

该基因编码 OX-2 膜糖蛋白的受体。受体和底物都是含有两个免疫球蛋白样结构域的细胞表面糖蛋白。这种受体仅限于髓系细胞的表面，受体-底物相互作用可能起到髓系下调信号的作用。相关基因的小鼠研究表明，这种相互作用可能以组织特异性方式控制骨髓功能。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

CD200R1 基因产物(4)

mRNA Protein Name
NM_138806.4 NP_620161.1 cell surface glycoprotein CD200 receptor 1 isoform a precursor
NM_138939.3 NP_620385.1 cell surface glycoprotein CD200 receptor 1 isoform b precursor
NM_138940.3 NP_620386.1 cell surface glycoprotein CD200 receptor 1 isoform c precursor
NM_170780.3 NP_740750.1 cell surface glycoprotein CD200 receptor 1 isoform d precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21982860 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
19151626 GOA
part of receptor complex IDA
IDA: 通过直接分析推断
23382219 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD200R1 蛋白结构

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (151 - 222)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
蛋白主名 其他名称

cell surface glycoprotein CD200 receptor 1

CD200 cell surface glycoprotein receptor

CD200R1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CD200R1 Q8TD46 CD200 Homo sapiens P41217
Protein Array
21982860
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD200R1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72749 CD200R1 Protein, Human (HEK293, His) Q8TD46-4 (A27-L266) ≥95%
HY-P75622 CD200R1 Protein, Human (HEK293, His-Fc) Q8TD46-4 (A27-L266) ≥95%
HY-P77599 CD200R1 Protein, Human (HEK293, Fc) Q8TD46-4 (A27-L266) ≥95%
HY-P77600 CD200R1 Protein, Human (HEK293, His-Avi) Q8TD46-4 (A27-L266) ≥95%
HY-P77601 CD200R1 Protein, Human (Biotinylated, HEK293, His-Avi) Q8TD46-4 (A27-L266) ≥95%

关联疾病

疾病名称 别名
Human Herpesvirus 8

HHV8S

Human Herpesvirus 8, Susceptibility To

Hhv-8

Hhv-8, Susceptibility To

HHV8

Kaposi Sarcoma
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

Plosl

Nhd

Presenile Dementia With Bone Cysts

Plo-Sl

PLOSL1

Dementia, Prefrontal, With Bone Cysts

Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease

Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02206 CD200R1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02207 CD200R1L Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990479 Anti-OX2R/CD200R1 Antibody Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CD200R1 RGD RGD:61837
Macaca mulatta CD200R1 VGNC VGNC:70845
Macaca fascicularis CD200R1 NCBI NCBI:102139962
Mus musculus CD200R1 NCBI NCBI:57781
Others CD200R1 NCBI
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