CD200R1 蛋白, Human (HEK293, Fc)

The CD200R1 protein is an inhibitory receptor that regulates key interactions by binding to the CD200/OX2 glycoprotein to limit inflammation by inhibiting TNF-α, interferon, and iNOS. Interestingly, CD200R1 displays comparable affinity and kinetics to the human herpesvirus 8 K14 viral CD200 homologue, reflecting its host CD200 interaction. CD200R1 Protein, Human (HEK293, Fc) is the recombinant human-derived CD200R1 protein, expressed by HEK293 , with C-hFc labeled tag.

CD200R1 是一种抑制性受体，通过与 CD200/OX2 细胞表面糖蛋白结合而充当关键调节剂。其调节作用延伸到通过抑制促炎分子（包括 TNF-α、干扰素和诱导型一氧化氮合酶 (iNOS)）来限制炎症，以响应特定的刺激。有趣的是，CD200R1 在与人疱疹病毒 8 K14 病毒 CD200 同源物结合时表现出相当的亲和力和动力学，反映了其与宿主 CD200 的相互作用。CD200 和 CD200R1 之间的相互作用是通过它们各自的 N 端 Ig 样结构域促进的，强调了这种分子相互作用的重要性。此外，CD200R1 与人类疱疹病毒 8 vOX2 蛋白结合，进一步扩展其在细胞过程中的多功能相互作用。

Measured by its binding ability in a functional ELISA. When Human CD200 is immobilized at 0.5 µg/mL (100 µL/well), Human CD200 R1 binds with an EC₅₀ of 26.6 ng/mL.

Human

HEK293

C-hFc

Q8TD46-4 (A27-L266)

131450  [NCBI]

53.7 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.