2. Gene
  3. LRRC15 - leucine rich repeat containing 15 Gene

LRRC15 - leucine rich repeat containing 15 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含富含亮氨酸的重复序列 15

种属: Homo sapiens

同用名: LIB

基因 ID: 131578 | 基因类型: protein coding

关于 LRRC15

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:194,355,249-194,369,743 (from NCBI)

This gene has 2 transcripts (splice variants), 112 orthologues and 22 paralogues. Broad expression in endometrium (RPKM 1.9), gall bladder (RPKM 1.2) and 15 other tissues.

功能概要

启用胶原蛋白结合活性；纤连蛋白结合活性；和层粘连蛋白结合活性。参与蛋白质定位到质膜的负调节；细胞迁移的正调控；和受体介导的病毒体附着于宿主细胞。位于细胞外外泌体。与含胶原蛋白的细胞外基质共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables collagen binding activity; fibronectin binding activity; and laminin binding activity. Involved in negative regulation of protein localization to plasma membrane; positive regulation of cell migration; and receptor-mediated virion attachment to host cell. Located in extracellular exosome. Colocalizes with collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

LRRC15 基因产物(2)

mRNA Protein Name
NM_001135057.3 NP_001128529.2 leucine-rich repeat-containing protein 15 isoform a precursor
NM_130830.5 NP_570843.2 leucine-rich repeat-containing protein 15 isoform b precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables collagen binding IDA
IDA: 通过直接分析推断
16098915 GOA
enables fibronectin binding IDA
IDA: 通过直接分析推断
16098915 GOA
enables laminin binding IDA
IDA: 通过直接分析推断
16098915 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
36228039 GOA
enables protein sequestering activity IDA
IDA: 通过直接分析推断
36228039 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of protein localization to plasma membrane IMP
IMP: 通过突变表型推断
18385238 GOA
involved in negative regulation of viral entry into host cell IDA
IDA: 通过直接分析推断
36228039 GOA
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
16098915 GOA
involved in receptor-mediated virion attachment to host cell IDA
IDA: 通过直接分析推断
36228039 GOA
involved in receptor-mediated virion attachment to host cell IMP
IMP: 通过突变表型推断
18385238 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in apical plasma membrane IDA
IDA: 通过直接分析推断
36228039 GOA
colocalizes with collagen-containing extracellular matrix IDA
IDA: 通过直接分析推断
16098915 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
36228039 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LRRC15 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (81 - 137)

LRR_1

LRR_1: Leucine Rich Repeat (150 - 172)

LRR_8

LRR_8: Leucine rich repeat (175 - 233)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (246 - 286)

LRR_8

LRR_8: Leucine rich repeat (293 - 353)

LRR_8

LRR_8: Leucine rich repeat (366 - 423)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 581 a.a.
蛋白主名 其他名称

leucine-rich repeat-containing protein 15

hLib

重组 LRRC15 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72512 LRRC15 Protein, Human (HEK293, His) Q8TF66-1 (Y22-G538) ≥95%
HY-P76480 LRRC15 Protein, Human (HEK293, Fc) Q8TF66-1 (Y22-G538) ≥95%
HY-P78172 LRRC15 Protein, Human (Biotinylated, HEK293, His-Avi) Q8TF66-1 (Y22-G538) ≥95%
HY-P78486 LRRC15 Protein, Human (HEK293, His-Avi) Q8TF66-1 (Y22-G538) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07808 LRRC15 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus LRRC15 VGNC VGNC:97483
Bos taurus LRRC15 VGNC VGNC:31001
Rattus norvegicus LRRC15 RGD RGD:70551
Macaca mulatta LRRC15 VGNC VGNC:74322
Canis familiaris LRRC15 VGNC VGNC:42786
Mus musculus LRRC15 MGD MGI:1921738
Macaca fascicularis LRRC15 NCBI NCBI:102144360
Others LRRC15 NCBI
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