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  2. IL17RE - interleukin 17 receptor E Gene

IL17RE - interleukin 17 receptor E Gene

中文名称:白介素 17 受体 E

种属: Homo sapiens

基因 ID: 132014 | 基因类型: protein coding

关于 IL17RE

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,902,093-9,916,402 (from NCBI)

This gene has 11 transcripts (splice variants), 180 orthologues and 4 paralogues. Broad expression in duodenum (RPKM 10.6), skin (RPKM 9.9) and 17 other tissues.

功能概要

该基因编码一种跨膜蛋白,作为白细胞介素 17C 的受体发挥作用。编码的蛋白质向有丝分裂原活化蛋白激酶 (MAPK) 通路的下游组分发出信号。这种蛋白质的活性在对细菌病原体的免疫反应中很重要。已经描述了该基因的可变剪接转录物变体。[RefSeq 提供,2013 年 9 月]

This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to Bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

IL17RE 基因产物(4)

mRNA Protein Name
NM_001193380.2 NP_001180309.1 interleukin-17 receptor E isoform 6 precursor
NM_153480.2 NP_705613.1 interleukin-17 receptor E isoform 1 precursor
NM_153481.2 NP_705614.1 interleukin-17 receptor E isoform 2
NM_153483.2 NP_705616.2 interleukin-17 receptor E isoform 5
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21993848 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

IL17RE 蛋白结构

IL17_R_N

IL17_R_N: Interleukin-17 receptor extracellular region (30 - 448)

SEFIR

SEFIR: SEFIR domain (488 - 561)

SEFIR

SEFIR: SEFIR domain (589 - 626)

  • 0
  • 200
  • 400
  • 600
  • 667 a.a.
蛋白主名 其他名称

interleukin-17 receptor E

IL-17 receptor E

IL17RE 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IL17RE Q8NFR9 IL17RA Homo sapiens Q96F46
Anti Tag CoIP
21993848
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 IL17RE 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72576 IL-17RE Protein, Human (HEK293, Fc) Q8NFR9-1 (T155-H454) ≥95%

关联疾病

疾病名称 别名
Cutaneous Candidiasis

Candidiasis, Cutaneous

Seborrheic Infantile Dermatitis

Cradle Cap

Infantile Seborrhoeic Dermatitis

Seborrhoea Capitis

Seborrhoeic Dermatitis Of Scalp

Seborrhoeic Eczema Of Scalp

Complement 5 Dysfunction

Generalized Seborrheic Dermatitis Of Infants

Infantile Seborrheic Dermatitis

Pityriasis Capitis

Seborrhea Capitis

Seborrhea Sicca

Dandruff

Complement Component 5 Deficiency

Seborrheic Dermatitis

Seborrheic Dermatitis Of Scalp

Scurfiness Of Scalp

Seborrheic Dermatitis Of Infancy

Infantile Seborrhoeic Eczema

Neonatal Seborrhoeic Dermatitis

Infantile Seborrhoeic Dermatitis Of The Scalp

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous

Cmc

Candidiasis Chronic Mucocutaneous

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus IL17RE VGNC VGNC:97464
Mus musculus IL17RE MGD MGI:1889371
Macaca mulatta IL17RE VGNC VGNC:73623
Canis familiaris IL17RE VGNC VGNC:41950
Rattus norvegicus IL17RE RGD RGD:735148
Bos taurus IL17RE VGNC VGNC:30125
Others IL17RE NCBI