IL31RA - interleukin 31 receptor A Gene

中文名称：白介素 31 受体 A

种属: Homo sapiens

同用名: CRL; GPL; CRL3; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384; zcytoR17

基因 ID: 133396 | 基因类型: protein coding

关于 IL31RA

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,839,789-55,922,850 (from NCBI)

This gene has 13 transcripts (splice variants), 174 orthologues, 23 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质属于 I 型细胞因子受体家族。这种与 gp130 同源的受体在单核细胞上表达，并通过激活 STAT-3 和 STAT-5 参与 IL-31 信号传导。它既可以作为单体，也可以作为与制瘤素 M 受体 (OSMR) 形成的受体复合物的一部分。已经注意到该基因有几种编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 6 月]

The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

IL31RA 基因产物(6)

mRNA	Protein	Name
NM_001242636.2	NP_001229565.1	interleukin-31 receptor subunit alpha isoform 2 precursor
NM_001242637.2	NP_001229566.1	interleukin-31 receptor subunit alpha isoform 3
NM_001242638.2	NP_001229567.1	interleukin-31 receptor subunit alpha isoform 4 precursor
NM_001242639.2	NP_001229568.1	interleukin-31 receptor subunit alpha isoform 5
NM_001297570.3	NP_001284499.1	interleukin-31 receptor subunit alpha isoform 6
NM_139017.7	NP_620586.3	interleukin-31 receptor subunit alpha isoform 1

基因本体论

生物过程

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell surface receptor signaling pathway via JAK-STAT	IEP IEP: 通过表达模式推断	11877449	GOA
involved in monocyte differentiation	IEP IEP: 通过表达模式推断	11877449	GOA
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	11877449	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IEP IEP: 通过表达模式推断	11877449	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL31RA 蛋白结构

IL6Ra-bind

fn3

0
200
400
600
764 a.a.

蛋白主名

其他名称

interleukin-31 receptor subunit alpha

IL-31 receptor subunit alpha

重组 IL31RA 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75859	IL-31R alpha Protein, Human (HEK293, Fc)	Q8NI17-1/EAW54932.1 (A20-S516)	≥95%
HY-P75860	IL-31R alpha Protein, Human (HEK293, His)	Q8NI17-1/EAW54932.1 (A20-S516)	≥95%

关联疾病

疾病名称

别名

Amyloidosis, Primary Localized Cutaneous, 2

PLCA2

Primary Localized Cutaneous Amyloidosis 2

Primary Cutaneous Amyloidosis

Plca	Primary Localized Cutaneous Amyloidosis
Familial Primary Localized Cutaneous Amyloidosis	Amyloidosis Ix
Lichen Amyloidosis Familial	Amyloidosis, Primary Cutaneous
Pca	Amyloidosis 9
Amyloidosis Familial Cutaneous Lichen	Fplca
Familial Lichen Amyloidosis

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Lichen Amyloidosis

Amyloid Lichen	Lichen Amyloidosus
Amyloidosis, Primary Cutaneous

Macular Amyloidosis

Amyloidosis, Macular

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Amyloidosis, Primary Localized Cutaneous, 3

Amyloidosis Cutis Dyschromica	PLCA3
Acd	Primary Localized Cutaneous Amyloidosis 3
Amyloidosis Cutis Dyschromia

Neurodermatitis

Contact Dermatitis

Contact Dermatitis/Eczema	Contact Eczema
Dermatitis Venenata	Dermatitis, Venenata
Dermatitis Contact	Dermatitis, Contact

Allergic Contact Dermatitis

Dermatitis, Allergic Contact	Contact Dermatitis, Allergic
Dermatitis Allergic Contact	Allergic Contact Eczema
Acd - [Allergic Contact Dermatitis]	Allergic Contact Dermatitis, Unspecified Cause
Allergic Dermatitis	Allergic Eczema
Allergy Dermatitis	Allergy Eczema
Allergic Contact Eczema Due To Clothing Or Footwear	Perfume Allergic Contact Dermatitis
Allergic Contact Dermatitis Due To Cosmetics	Allergic Contact Eczema Due To Cosmetics Or Fragrances
Allergic Contact Eczema Due To Dental Materials	Allergic Contact Eczema Due To Food Flavours Or Additives
Allergic Contact Eczema Due To Hairdressing Products	Allergic Contact Eczema Due To Metals Or Metal Salts
Allergic Contact Eczema Due To Proteins	Allergic Contact Eczema Due To Plastics Or Resin Systems
Allergic Contact Eczema Due To Preservatives Or Biocides	Allergic Contact Eczema Due To Rubber Chemicals
Rubber Dermatitis	Allergic Contact Eczema Due To Systemic Medicaments
Allergic Contact Eczema Due To Topical Medicaments	Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Congenital Central Hypoventilation Syndrome

Cchs	Haddad Syndrome
Ondine Curse	Ondine Syndrome
Congenital Central Hypoventilation	Congenital Central Alveolar Hypoventilation Syndrome
Congenital Failure Of Autonomic Control	Ondine'S Curse
Primary Alveolar Hypoventilation	Ondine-Hirschsprung Disease
Central Congenital Hypoventilation Syndrome	Congenital Ondine Curse
Idiopathic Congenital Central Alveolar Hypoventilation	Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome
Ondine-Hirschsprung Syndrome

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06755	IL31RA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990713	Nolavetbart		/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	IL31RA	MGD	MGI:2180511
Rattus norvegicus	IL31RA	RGD	RGD:1586478
Macaca mulatta	IL31RA	VGNC	VGNC:73624
Bos taurus	IL31RA	VGNC	VGNC:30154
Felis catus	IL31RA	VGNC	VGNC:62911
Canis familiaris	IL31RA	VGNC	VGNC:41981
Others	IL31RA	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

IL31RA - interleukin 31 receptor A Gene

关于 IL31RA

功能概要

IL31RA 基因产物(6)

IL31RA 蛋白结构

重组 IL31RA 蛋白

关联疾病

直系同源

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IL31RA - interleukin 31 receptor A Gene

关于 IL31RA

功能概要

IL31RA 基因产物(6)

IL31RA 蛋白结构

重组 IL31RA 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z