2. Gene
  3. CPB1 - carboxypeptidase B1 Gene

CPB1 - carboxypeptidase B1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：羧肽酶 B1

种属: Homo sapiens

同用名: CPB; PASP; PCPB

基因 ID: 1360 | 基因类型: protein coding

关于 CPB1

Cytogenetic location: 3q24 Genomic coordinates (GRCh38): 3:148,827,811-148,860,187 (from NCBI)

This gene has 10 transcripts (splice variants), 220 orthologues and 8 paralogues. Restricted expression toward pancreas (RPKM 27892.6).

功能概要

已经分离出三种不同的羧肽酶原 A 和两种不同的羧肽酶原 B。 B1 和 B2 形式的主要区别在于等电点。羧肽酶 B1 是一种高度组织特异性的蛋白质，是急性胰腺炎和胰腺移植功能障碍的有用血清标志物。它在胰腺癌中不升高。[RefSeq 提供，2008 年 7 月]

Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]

CPB1 基因产物(1)

mRNA Protein Name
NM_001871.3 NP_001862.2 carboxypeptidase B preproprotein
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables carboxypeptidase activity IDA
IDA: 通过直接分析推断
1370825 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within proteolysis IDA
IDA: 通过直接分析推断
1370825 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CPB1 蛋白结构

Propep_M14

Propep_M14: Carboxypeptidase activation peptide (28 - 104)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (125 - 403)

  • 0
  • 100
  • 200
  • 300
  • 417 a.a.
蛋白主名 其他名称

carboxypeptidase B

carboxypeptidase B1 (tissue)

重组 CPB1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7734 Carboxypeptidase B1/CPB1 Protein, Human (HEK293, His) P15086 (H16-Y417) ≥95%

关联疾病

疾病名称 别名
Acute Pancreatitis

Pancreatitis

Pancreatitis, Acute Necrotizing

Pancreatitis Nos

Acute Pancreas Inflammation
Pancreatitis

Mumps Pancreatitis
Alcoholic Pancreatitis

Pancreatitis, Alcoholic

Pancreatitis Alcoholic
Gas Gangrene

Myonecrosis

Gas Bacillus Infection

Gas Gangrene Due To Clostridia

Clostridial Myonecrosis

Clostridial Cellulitis
Cardiomyopathy, Familial Hypertrophic, 10

Hypertrophic Cardiomyopathy 10

CMH10

Cardiomyopathy, Hypertrophic, Mid-Left Ventricular Chamber Type, 2

Cardiomyopathy, Hypertrophic, 10

Cardiomyopathy, Familial Hypertrophic 10

Familial Hypertrophic Cardiomyopathy With Mid-Left Ventricular Chamber Type 2

Mvc2

Cardiomyopathy, Hypertrophic, Familial, Type 10
C Syndrome

Opitz Trigonocephaly Syndrome

Trigonocephaly

Trigonocephaly Syndrome

Trigonocephaly C Syndrome

Opitz C Trigonocephaly

Opitz Trigonocephaly C Syndrome

Otcs

CSYN
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03087 CPB1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CPB1 VGNC VGNC:27645
Mus musculus CPB1 MGD MGI:1923953
Canis familiaris CPB1 VGNC VGNC:39549
Felis catus CPB1 VGNC VGNC:61117
Macaca mulatta CPB1 VGNC VGNC:110372
Rattus norvegicus CPB1 RGD RGD:2391
Others CPB1 NCBI
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