2. Gene
  3. CPD - carboxypeptidase D Gene

CPD - carboxypeptidase D Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：羧肽酶 D

种属: Homo sapiens

同用名: GP180

基因 ID: 1362 | 基因类型: protein coding

关于 CPD

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:30,378,927-30,469,989 (from NCBI)

This gene has 10 transcripts (splice variants), 219 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 44.8), gall bladder (RPKM 23.6) and 24 other tissues.

功能概要

基于序列相似性，金属羧肽酶家族分为 2 个亚家族。胰羧肽酶样和调节性 B 型羧肽酶亚家族。羧肽酶 D 已被鉴定为调节性 B 型羧肽酶。 CPD 是鸭 gp180 的同源物，一种乙型肝炎病毒结合蛋白。该基因存在利用替代聚腺苷酸化信号的转录变体。[RefSeq 提供，2008 年 7 月]

The metallocarboxypeptidase family of Enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type Carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type Carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]

CPD 基因产物(2)

mRNA Protein Name
NM_001199775.1 NP_001186704.1 carboxypeptidase D isoform 2
NM_001304.5 NP_001295.2 carboxypeptidase D isoform 1 precursor

CPD 蛋白结构

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (71 - 371)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (384 - 459)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (510 - 782)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (796 - 870)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (941 - 1201)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (1215 - 1285)

  • 0
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  • 1380 a.a.
蛋白主名 其他名称

carboxypeptidase D

metallocarboxypeptidase D

关联疾病

疾病名称 别名
Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos
Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (21)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153386 CPD-1224 Inhibitor 99.24% 否
HY-112338 C188 Inhibitor ≥97.0% 否
HY-158009 SGF29-IN-1 Inhibitor ≥98.0% 否
HY-143498 ERCC1-XPF-IN-1 Inhibitor / 否
HY-163705 BR-cpd7 Degrader 98.01% 否
HY-158142 PROTAC TYK2 degrader-1 Degrader / 否
HY-134621 P300-IN-1 Inhibitor / 否
HY-144028 Pan-Trk-IN-2 Inhibitor / 否
HY-147310 CU-CPD107 Agonist 98.07% 否
HY-153441 AXL-IN-15 Inhibitor / 否
HY-161606 PARP-1/2/7-IN-1 Inhibitor / 否
HY-161607 PARP7-IN-21 Inhibitor / 否
HY-163533 CPD-002 Inhibitor / 否
HY-169059 Ferroptosis-IN-12 Inhibitor / 否
HY-N7893 Ebracteolata cpd B / 否
HY-P4523 FA-Ala-Arg / 否
HY-RS03089 CPD Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W471937 α1B-AR antagonist 1 Antagonist / 否
HY-158340 TYK2 ligand 1 Inhibitor / 否
HY-160167 BTK-IN-30 Inhibitor / 否
HY-W585819 3-Chloropropane-1,2-diol dipalmitate / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CPD VGNC VGNC:39551
Bos taurus CPD VGNC VGNC:27647
Rattus norvegicus CPD RGD RGD:2393
Mus musculus CPD MGD MGI:107265
Felis catus CPD VGNC VGNC:61119
Macaca mulatta CPD VGNC VGNC:99139
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