2. Gene
  3. LRGUK - leucine rich repeats and guanylate kinase domain containing Gene

LRGUK - leucine rich repeats and guanylate kinase domain containing Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含富含亮氨酸的重复序列和鸟苷酸激酶结构域

种属: Homo sapiens

同用名: CFAP246

基因 ID: 136332 | 基因类型: protein coding

关于 LRGUK

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:134,127,340-134,276,685 (from NCBI)

This gene has 5 transcripts (splice variants), 193 orthologues and 13 paralogues. Biased expression in testis (RPKM 1.3), lung (RPKM 0.2) and 7 other tissues.

功能概要

预测启用鸟苷酸激酶活性。预计参与轴丝组装和精子发生。预测位于顶体小泡和 manchette。预计在胞质溶胶中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable guanylate kinase activity. Predicted to be involved in axoneme assembly and spermatogenesis. Predicted to be located in acrosomal vesicle and manchette. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

LRGUK 基因产物(4)

mRNA Protein Name
NM_001365700.3 NP_001352629.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform 1
NM_001365701.3 NP_001352630.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform 2
NM_001401519.1 NP_001388448.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform 4
NM_144648.3 NP_653249.1 leucine-rich repeat and guanylate kinase domain-containing protein isoform 3

LRGUK 蛋白结构

(150 - 164)

LRR_9

LRR_9: Leucine-rich repeat (264 - 375)

Guanylate_kin

Guanylate_kin: Guanylate kinase (416 - 598)

  • 0
  • 200
  • 400
  • 600
  • 825 a.a.
蛋白主名 其他名称

leucine-rich repeat and guanylate kinase domain-containing protein

LRGUK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LRGUK Q96M69 HOOK2 Homo sapiens Q96ED9-2
Y2H Array
32296183
种属内
LRGUK Q96M69 HOOK2 Homo sapiens Q96ED9-2
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07785 LRGUK Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LRGUK VGNC VGNC:74334
Mus musculus LRGUK MGD MGI:1921604
Felis catus LRGUK VGNC VGNC:63279
Rattus norvegicus LRGUK RGD RGD:1308226
Bos taurus LRGUK VGNC VGNC:52794
Canis familiaris LRGUK VGNC VGNC:54786
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