2. Gene
  3. UNC5D - unc-5 netrin receptor D Gene

UNC5D - unc-5 netrin receptor D Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：unc-5 netrin 受体 D

种属: Homo sapiens

同用名: Unc5h4; PRO34692

基因 ID: 137970 | 基因类型: protein coding

关于 UNC5D

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:35,235,475-35,796,540 (from NCBI)

This gene has 7 transcripts (splice variants), 279 orthologues and 4 paralogues. Biased expression in brain (RPKM 2.7), duodenum (RPKM 2.4) and 8 other tissues.

功能概要

预测启用 netrin 受体活性。通过质膜粘附分子参与细胞间粘附。预计位于细胞表面和质膜。预计是膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable netrin receptor activity. Involved in cell-cell adhesion via plasma-membrane adhesion molecules. Predicted to be located in cell surface and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

UNC5D 基因产物(3)

mRNA Protein Name
NM_001322818.2 NP_001309747.1 netrin receptor UNC5D isoform 2
NM_001410918.1 NP_001397847.1 netrin receptor UNC5D isoform 3 precursor
NM_080872.4 NP_543148.2 netrin receptor UNC5D isoform 1 precursor
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell-cell adhesion via plasma-membrane adhesion molecules IDA
IDA: 通过直接分析推断
26235030 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UNC5D 蛋白结构

I-set

I-set: Immunoglobulin I-set domain (160 - 247)

TSP_1

TSP_1: Thrombospondin type 1 domain (256 - 302)

TSP_1

TSP_1: Thrombospondin type 1 domain (313 - 359)

ZU5

ZU5: ZU5 domain (542 - 641)

Death

Death: Death domain (860 - 929)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 953 a.a.
蛋白主名 其他名称

netrin receptor UNC5D

netrin receptor Unc5h4

关联疾病

疾病名称 别名
Anisometropia
Severe Congenital Neutropenia 4

Autosomal Recessive Severe Congenital Neutropenia Due To G6pc3 Deficiency

Scn4

Severe Congenital Neutropenia-Pulmonary Hypertension-Superficial Venous Angiectasis Syndrome

Dursun Syndrome

Severe Congenital Neutropenia Type 4
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15474 UNC5D Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus UNC5D MGD MGI:2389364
Felis catus UNC5D VGNC VGNC:66832
Rattus norvegicus UNC5D RGD RGD:1309245
Macaca mulatta UNC5D VGNC VGNC:79158
Bos taurus UNC5D VGNC VGNC:36674
Canis familiaris UNC5D VGNC VGNC:48143
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