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  3. CRABP1 - cellular retinoic acid binding protein 1 Gene

CRABP1 - cellular retinoic acid binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞视黄酸结合蛋白 1

种属: Homo sapiens

同用名: RBP5; CRABP; CRABPI; CRABP-I

基因 ID: 1381 | 基因类型: protein coding

关于 CRABP1

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,340,353-78,348,225 (from NCBI)

This gene has 3 transcripts (splice variants), 258 orthologues and 15 paralogues. Biased expression in thyroid (RPKM 65.7), spleen (RPKM 23.2) and 3 other tissues.

功能概要

该基因编码维生素 A 家族成员的特异性结合蛋白，被认为在视黄酸介导的分化和增殖过程中发挥重要作用。它在结构上类似于细胞视黄醇结合蛋白，但仅在细胞核内的特定位点结合视黄酸，这可能有助于上皮组织中维生素 A 定向分化。[RefSeq 提供，2008 年 7 月]

This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]

CRABP1 基因产物(1)

mRNA Protein Name
NM_004378.3 NP_004369.1 cellular retinoic acid-binding protein 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15607035 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRABP1 蛋白结构

Lipocalin

Lipocalin: Lipocalin / cytosolic fatty-acid binding protein family (5 - 137)

  • 0
  • 100
  • 137 a.a.
蛋白主名 其他名称

cellular retinoic acid-binding protein 1

cellular retinoic acid-binding protein I

CRABP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CRABP1 P29762 TH Homo sapiens P07101-3
Y2H Array
32296183
种属内
CRABP1 P29762 TH Homo sapiens P07101-3
Y2H Prey Pooling
32296183
种属内
CRABP1 P29762 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
种属间
CRABP1 P29762 P27958-PRO_0000037576 Hepatitis C virus P27958-PRO_0000037576
Pull Down
15607035
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CRABP1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75687 CRABP1 Protein, Human AAH22069.1 (M1-E137) ≥95%

CRABP1 抗体

目录号 产品名 应用 反应物种
HY-P82722 CRABP1 Antibody (YA2467) WB, IP Human, Mouse

关联疾病

疾病名称 别名
Teratocarcinoma

Mixed Embryonal Carcinoma And Teratoma
Embryonal Carcinoma

Embryonal Neoplasm

Embryonal Cancer

Primary Extragonadal Embryonal Carcinoma

Embryo Neoplasm

Carcinoma Embryonal

Cancer Embryonal

Carcinoma, Embryonal

Extragonadal Embryonal Carcinoma

Cancer, Embryonal
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Witkop Syndrome

Tooth And Nail Syndrome

Hypoplastic Enamel-Onycholysis-Hypohidrosis Syndrome

Tns

Ectodermal Dysplasia 3, Witkop Type

ECTD3

Ectodermal Dysplasia 3, Tooth/Nail Type

Tooth-And-Nail Syndrome

Dysplasia Of Nails With Hypodontia

Nail Dysplasia With Hypodontia

Witkop'S Syndrome

Hypodontia - Dysplasia Of Nails

Hypodontia-Dysplasia Of Nails Syndrome

Hypodontia-Nail Dysgenesis Syndrome

Hypodontia-Nail Dysgenesis
Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos
Keratoacanthoma

Ka - [Keratoacanthoma]

Well-Differentiated Squamous Cell Carcinoma
Hypervitaminosis A

Hypervitaminosis A, Susceptibility To

Hyperalimentation Of Vitamin A
Moyamoya Disease 1

Moyamoya Disease

Spontaneous Occlusion Of The Circle Of Willis

Mymy

Progressive Intracranial Arterial Occlusion

Moyamoya Syndrome

MYMY1

Cerebrovascular Moyamoya Disease

Moya-Moya Disease

Progressive Intracranial Occlusive Arteropathy

Idiopathic Moyamoya Disease
Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0444 Maprotiline hydrochloride 99.98% 否
HY-B0444R Maprotiline (hydrochloride) (Standard) / 否
HY-B0444A Maprotiline / 否
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03134 CRABP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CRABP1 VGNC VGNC:27685
Felis catus CRABP1 VGNC VGNC:61155
Macaca mulatta CRABP1 VGNC VGNC:71480
Rattus norvegicus CRABP1 RGD RGD:2400
Mus musculus CRABP1 MGD MGI:88490
Others CRABP1 NCBI
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