2. Gene
  3. Epha2 - Eph receptor A2 Gene

Epha2 - Eph receptor A2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Eck; Myk2; Sek2; Sek-2

基因 ID: 13836 | 基因类型: protein coding

关于 Epha2

功能概要

Predicted to enable growth factor binding activity and transmembrane-ephrin receptor activity. Involved in several processes, including animal organ development; osteoblast differentiation; and regulation of blood vessel endothelial cell migration. Acts upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and notochord development. Located in cell surface. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; endometrium; and limb. Used to study cataract 6 multiple types. Human ortholog(s) of this gene implicated in cataract 6 multiple types. Orthologous to human EphA2 (EPH receptor A2). [provided by Alliance of Genome Resources, Apr 2022]

Epha2 基因产物(1)

mRNA Protein Name
NM_010139.3 NP_034269.2 ephrin type-A receptor 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16782872 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within axial mesoderm formation IMP
IMP: 通过突变表型推断
11287184 MGI
acts upstream of or within blood vessel development IMP
IMP: 通过突变表型推断
11287184 MGI
acts upstream of or within blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
19443703 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: 通过突变表型推断
19443703 MGI
involved in bone remodeling IMP
IMP: 通过突变表型推断
19299512 MGI
involved in branching involved in mammary gland duct morphogenesis IMP
IMP: 通过突变表型推断
19321667 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: 通过突变表型推断
19443703 MGI
acts upstream of or within ephrin receptor signaling pathway IDA
IDA: 通过直接分析推断
14988728 MGI
involved in ephrin receptor signaling pathway IMP
IMP: 通过突变表型推断
18948590 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
19443703 MGI
involved in lens fiber cell morphogenesis IDA
IDA: 通过直接分析推断
18948590 MGI
involved in mammary gland epithelial cell proliferation IMP
IMP: 通过突变表型推断
19321667 MGI
acts upstream of or within negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
19443703 MGI
acts upstream of or within negative regulation of chemokine production IMP
IMP: 通过突变表型推断
19443703 MGI
acts upstream of or within negative regulation of cytokine production IMP
IMP: 通过突变表型推断
19443703 MGI
acts upstream of or within negative regulation of lymphangiogenesis IMP
IMP: 通过突变表型推断
19443703 MGI
acts upstream of or within neural tube development IMP
IMP: 通过突变表型推断
11287184 MGI
acts upstream of or within neuron differentiation IDA
IDA: 通过直接分析推断
15145949 MGI
acts upstream of or within neuron differentiation IMP
IMP: 通过突变表型推断
15145949 MGI
acts upstream of or within notochord cell development IMP
IMP: 通过突变表型推断
11287184 MGI
acts upstream of or within notochord formation IGI
IGI: 通过遗传相互作用推断
11287184 MGI
acts upstream of or within notochord formation IMP
IMP: 通过突变表型推断
11287184 MGI
acts upstream of or within notochord morphogenesis IMP
IMP: 通过突变表型推断
11287184 MGI
involved in osteoblast differentiation IMP
IMP: 通过突变表型推断
19299512 MGI
involved in osteoclast differentiation IDA
IDA: 通过直接分析推断
19299512 MGI
acts upstream of or within pericyte cell differentiation IMP
IMP: 通过突变表型推断
19443703 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: 通过突变表型推断
11287184 MGI
involved in regulation of angiogenesis IDA
IDA: 通过直接分析推断
16782872 MGI
involved in regulation of blood vessel endothelial cell migration IDA
IDA: 通过直接分析推断
16782872 MGI
acts upstream of or within skeletal system development IMP
IMP: 通过突变表型推断
11287184 MGI
acts upstream of or within vasculogenesis IMP
IMP: 通过突变表型推断
11287184 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
27733379 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ephrin type-A receptor 2

epithelial cell kinase

tyrosine-protein kinase receptor ECK

tyrosine-protein kinase receptor MPK-5

tyrosine-protein kinase receptor SEK-2

Epha2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Epha2 Q03145 Epha4 Mus musculus Q03137
Protein Kinase Assay
16977320
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Epha2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75240 EphA2 Protein, Mouse (HEK293, His) Q03145 (K26-N535) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-163835 UniPR1454 Antagonist / 否
HY-159174 EPHA2/A4/GAK-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Epha2 NCBI NCBI:1969
Macaca fascicularis Epha2 NCBI NCBI:102146108
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