2. Gene
  3. Epha4 - Eph receptor A4 Gene

Epha4 - Eph receptor A4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: rb; Sek; Cek8; Hek8; Sek1; Tyro1; 2900005C20Rik

基因 ID: 13838 | 基因类型: protein coding

关于 Epha4

功能概要

Enables GPI-linked Ephrin Receptor activity; identical protein binding activity; and transmembrane-ephrin receptor activity. Involved in several processes, including axon development; positive regulation of protein kinase activity; and regulation of neuron projection development. Acts upstream of or within adult walking behavior; axon guidance; and nephric duct morphogenesis. Located in several cellular components, including Schaffer collateral - CA1 synapse; early endosome membrane; and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Orthologous to human EphA4 (EPH receptor A4). [provided by Alliance of Genome Resources, Apr 2022]

Epha4 基因产物(1)

mRNA Protein Name
NM_007936.3 NP_031962.2 ephrin type-A receptor 4 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GPI-linked ephrin receptor activity IMP
IMP: 通过突变表型推断
17143272 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16977320 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16977320 MGI
enables transmembrane receptor protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
31439799 MGI
enables transmembrane-ephrin receptor activity IDA
IDA: 通过直接分析推断
17719550 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adherens junction organization IMP
IMP: 通过突变表型推断
30639848 MGI
acts upstream of or within adult walking behavior IMP
IMP: 通过突变表型推断
12649481 MGI
acts upstream of or within axon guidance IGI
IGI: 通过遗传相互作用推断
23144223 MGI
acts upstream of or within axon guidance IMP
IMP: 通过突变表型推断
12649481 MGI
involved in cellular response to amyloid-beta IGI
IGI: 通过遗传相互作用推断
24658113 MGI
involved in cochlea development IMP
IMP: 通过突变表型推断
30639848 MGI
involved in corticospinal tract morphogenesis IMP
IMP: 通过突变表型推断
9789074 MGI
involved in fasciculation of motor neuron axon IMP
IMP: 通过突变表型推断
18403711 MGI
involved in fasciculation of sensory neuron axon IMP
IMP: 通过突变表型推断
18403711 MGI
acts upstream of or within innervation IMP
IMP: 通过突变表型推断
29518482 MGI
involved in motor neuron axon guidance IMP
IMP: 通过突变表型推断
17785183 MGI
involved in negative regulation of axon regeneration IMP
IMP: 通过突变表型推断
15537875 MGI
involved in negative regulation of long-term synaptic potentiation IGI
IGI: 通过遗传相互作用推断
24658113 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
29518482 MGI
involved in negative regulation of neuron projection development IDA
IDA: 通过直接分析推断
12761826 MGI
acts upstream of or within nephric duct morphogenesis IGI
IGI: 通过遗传相互作用推断
25139858 MGI
involved in neuron projection fasciculation IDA
IDA: 通过直接分析推断
12761826 MGI
involved in neuron projection guidance IDA
IDA: 通过直接分析推断
12761826 MGI
involved in positive regulation of JUN kinase activity IDA
IDA: 通过直接分析推断
10523642 MGI
involved in positive regulation of protein tyrosine kinase activity IGI
IGI: 通过遗传相互作用推断
24658113 MGI
involved in regulation of GTPase activity IDA
IDA: 通过直接分析推断
17719550 MGI
involved in regulation of GTPase activity IMP
IMP: 通过突变表型推断
18094260 MGI
involved in regulation of astrocyte differentiation IMP
IMP: 通过突变表型推断
15537875 MGI
involved in regulation of axonogenesis IMP
IMP: 通过突变表型推断
15537875 MGI
involved in regulation of dendritic spine morphogenesis IMP
IMP: 通过突变表型推断
17143272 MGI
involved in regulation of modification of synaptic structure IGI
IGI: 通过遗传相互作用推断
24658113 MGI
involved in synapse pruning EXP
EXP: 通过实验结果推断
12496762 MGI
involved in synapse pruning IDA
IDA: 通过直接分析推断
12496762 MGI
involved in synapse pruning IMP
IMP: 通过突变表型推断
12496762 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
18410519 MGI
is active in Schaffer collateral - CA1 synapse IEP
IEP: 通过表达模式推断
18410519 MGI
located in axon IDA
IDA: 通过直接分析推断
17143272 MGI
located in dendrite IDA
IDA: 通过直接分析推断
17143272 MGI
located in early endosome membrane IDA
IDA: 通过直接分析推断
17143272 MGI
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
12496762 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
12496762 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
18410519 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
12496762 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
17143272 MGI
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
18410519 MGI
is active in postsynaptic membrane IEP
IEP: 通过表达模式推断
18410519 MGI
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
18410519 MGI
is active in presynaptic membrane IEP
IEP: 通过表达模式推断
18410519 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ephrin type-A receptor 4

tyrosine-protein kinase receptor MPK-3

tyrosine-protein kinase receptor SEK-1

重组 Epha4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72995 EphA4 Protein, Mouse (HEK293, Fc) Q03137-1 (V20-T547) ≥95%
HY-P78293 EphA4 Protein, Mouse (HEK293, His) Q03137-1 (V20-T547) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-159174 EPHA2/A4/GAK-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Epha4 NCBI NCBI:2043
Rattus norvegicus Epha4 NCBI NCBI:316539
Macaca mulatta Epha4 NCBI NCBI:704857
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z