1. Gene
  2. SLITRK4 - SLIT and NTRK like family member 4 Gene

SLITRK4 - SLIT and NTRK like family member 4 Gene

中文名称:SLIT 和 NTRK 样家族成员 4

种属: Homo sapiens

基因 ID: 139065 | 基因类型: protein coding

关于 SLITRK4

Cytogenetic location: Xq27.3 Genomic coordinates (GRCh38): X:143,622,790-143,636,101 (from NCBI)

This gene has 3 transcripts (splice variants), 188 orthologues and 25 paralogues. Biased expression in adrenal (RPKM 4.6), brain (RPKM 4.3) and 9 other tissues.

功能概要

该基因编码属于 SLITRK 家族的跨膜蛋白。这些家族成员包括两个 N 末端富含亮氨酸的重复结构域,类似于在轴突生长控制蛋白 SLIT 中发现的结构域,以及类似于神经营养蛋白受体的 C 末端区域。对小鼠同源蛋白的研究表明,该家族成员具有抑制神经突生长的功能。可变剪接导致多个转录本变体。[RefSeq 提供,2010 年 5 月]

This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

SLITRK4 基因产物(3)

mRNA Protein Name
NM_001184749.3 NP_001171678.1 SLIT and NTRK-like protein 4 precursor
NM_001184750.2 NP_001171679.1 SLIT and NTRK-like protein 4 precursor
NM_173078.5 NP_775101.1 SLIT and NTRK-like protein 4 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of synapse organization IDA
IDA: 通过直接分析推断
23345436 GOA
involved in regulation of synapse organization IMP
IMP: 通过突变表型推断
23345436 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
23345436 GOA
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
23345436 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SLITRK4 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (62 - 119)

LRR_8

LRR_8: Leucine rich repeat (131 - 190)

LRR_8

LRR_8: Leucine rich repeat (425 - 485)

  • 0
  • 200
  • 400
  • 600
  • 837 a.a.
蛋白主名 其他名称

SLIT and NTRK-like protein 4

slit and trk like gene 4

SLITRK4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLITRK4 Q8IW52 CNPY3 Homo sapiens Q9BT09 33961781
种属内
SLITRK4 Q8IW52 CNPY3 Homo sapiens Q9BT09 28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SLITRK4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77207 SLITRK4 Protein, Human (HEK293, His) Q8IW52 (D19-P616) ≥95%

关联疾病

疾病名称 别名
Supratentorial Primitive Neuroectodermal Tumor

Supratentorial Pnet

Supratentorial Embryonal Tumor, Not Otherwise Specified

Ewings Sarcoma-Primitive Neuroectodermal Tumor

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLITRK4 MGD MGI:2442509
Macaca mulatta SLITRK4 VGNC VGNC:77762
Rattus norvegicus SLITRK4 RGD RGD:1588563
Bos taurus SLITRK4 VGNC VGNC:34965
Canis familiaris SLITRK4 VGNC VGNC:46509
Others SLITRK4 NCBI