1. Gene
  2. SPIN4 - spindlin family member 4 Gene

SPIN4 - spindlin family member 4 Gene

中文名称:纺锤家族成员 4

种属: Homo sapiens

同用名: TDRD28

基因 ID: 139886 | 基因类型: protein coding

关于 SPIN4

This gene has 1 transcript (splice variant), 230 orthologues and 4 paralogues.

功能概要

启用甲基化组蛋白结合活性。预计参与转录调控,以 DNA 为模板。预计在胞质溶胶和核质中具有活性。 [由基因组资源联盟提供,2022 年 4 月]

Enables methylated histone binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SPIN4 基因产物(1)

mRNA Protein Name
NM_001012968.3 NP_001012986.2 spindlin-4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables methylated histone binding IDA
IDA: 通过直接分析推断
29061846 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
29061846 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
36927955 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
36927955 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
36927955 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
36927955 GOA
located in nucleus IDA
IDA: 通过直接分析推断
36927955 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SPIN4 蛋白结构

Spin-Ssty

Spin-Ssty: Spin/Ssty Family (41 - 90)

Spin-Ssty

Spin-Ssty: Spin/Ssty Family (119 - 168)

Spin-Ssty

Spin-Ssty: Spin/Ssty Family (201 - 246)

  • 0
  • 100
  • 200
  • 249 a.a.
蛋白主名 其他名称

spindlin-4

关联疾病

疾病名称 别名
Hyperekplexia

Hereditary Hyperekplexia

Kok Disease

Congenital Stiff Man Syndrome

Familial Startle Disease

Sthe

Stiff-Baby Syndrome

Hereditary Hyperexplexia

Startle Disease

Exaggerated Startle Reaction

Hyperexplexia Hereditary

Startle Disease, Familial

Startle Reaction, Exaggerated

Stiff-Man Syndrome, Congenital

Stiff-Person Syndrome, Congenital

Congenital Stiff-Man Syndrome

Congenital Stiff-Person Syndrome

Familial Hyperekplexia

Startle Syndrome

Stiff Baby Syndrome

Hyperekplexia, Hereditary

Stiff-Person Syndrome

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa

Foramen Ovale Patent

Ostium Secundum Atrial Septal Defect

Atrial Septal Defect, Ostium Secundum Type

Foramen Ovale, Patent

Defect, Patent Or Persistent, Ostium Secundum

Ostium Secundum Type Atrial Septal Defect

Persistent Ostium Secundum

Asd Ostium Secundum Type

Ostium Secundum Asd

Osasd

Asd, Ostium Secundum Type

Pfo - [Patent Foramen Ovale]

Open Foramen Ovale

Open Oval Foramen

Persistent Foramen Ovale

Secundum Atrial Septal Defect

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression

Early Infantile Epileptic Encephalopathy With Suppression Bursts

Eiee

Early Infantile Epileptic Encephalopathy With Suppression-Bursts

Ohtahara Syndrome

Encephalopathy, Epileptic, Early Infantile

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SPIN4 VGNC VGNC:78004
Mus musculus SPIN4 MGD MGI:2444925
Bos taurus SPIN4 VGNC VGNC:35218
Rattus norvegicus SPIN4 RGD RGD:1564004
Felis catus SPIN4 VGNC VGNC:65638
Canis familiaris SPIN4 VGNC VGNC:46743
Others SPIN4 NCBI