Chek1 - checkpoint kinase 1 Gene

中文名称：检查点激酶 1

种属: Rattus norvegicus

关于 Chek1

功能概要

该基因编码的蛋白可启动蛋白激酶活性。参与多个过程，包括 DNA 损伤诱导的蛋白质磷酸化；细胞对咖啡因的反应；和有丝分裂细胞周期 G2/M 转换的负调控。预计位于几个细胞成分中，包括中心体；染色体;和核质。预计是含蛋白质复合物的一部分。预计活跃于核心。预测与染色体、端粒区域共定位。该基因的人类直系同源物与胰腺癌有关。与人类 CHEK1（检查点激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase activity. Involved in several processes, including DNA damage induced protein phosphorylation; cellular response to caffeine; and negative regulation of G2/M transition of mitotic cell cycle. Predicted to be located in several cellular components, including centrosome; chromosome; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human CHEK1 (checkpoint kinase 1). [provided by Alliance of Genome Resources, Apr 2022]