F2rl3 - coagulation factor II (thrombin) receptor-like 3 Gene

中文名称：凝血因子 II (凝血酶) 受体样 3

种属: Mus musculus

同用名: PAR4

关于 F2rl3

功能概要

该基因编码蛋白酶激活受体亚家族的成员，是 G 蛋白偶联受体 1 蛋白家族的一部分。编码的受体经过蛋白水解处理，以揭示结合并激活受体的细胞外 N 末端栓系配体。这种受体在血液凝固、炎症和对疼痛的反应中发挥作用。缺乏该基因功能拷贝的小鼠表现出血小板活化受损和出血时间延长。 [RefSeq 提供，2016 年 9 月]

This gene encodes a member of the Protease-activated Receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Mice lacking a functional copy of this gene exhibit impaired platelet activation and prolonged bleeding times. [provided by RefSeq, Sep 2016]