2. Gene
  3. Fkbp1b - FK506 binding protein 1b Gene

Fkbp1b - FK506 binding protein 1b Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: 12.6kDa; FKBP12.6; calstabin2

基因 ID: 14226 | 基因类型: protein coding

关于 Fkbp1b

功能概要

Enables FK506 binding activity; peptidyl-prolyl cis-trans isomerase activity; and transmembrane transporter binding activity. Involved in negative regulation of heart rate; regulation of cytosolic calcium ion concentration; and regulation of release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including Insulin secretion; negative regulation of Insulin secretion involved in cellular response to glucose stimulus; and neuronal action potential propagation. Located in sarcoplasmic reticulum membrane. Part of Calcium Channel complex. Is expressed in nervous system and testis. Used to study catecholaminergic polymorphic ventricular tachycardia. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to human FKBP1B (FKBP prolyl isomerase 1B). [provided by Alliance of Genome Resources, Apr 2022]

Fkbp1b 基因产物(4)

mRNA Protein Name
NM_001378816.1 NP_001365745.1 peptidyl-prolyl cis-trans isomerase FKBP1B isoform 2
NM_001378817.1 NP_001365746.1 peptidyl-prolyl cis-trans isomerase FKBP1B isoform 3
NM_001378818.1 NP_001365747.1 peptidyl-prolyl cis-trans isomerase FKBP1B isoform 4
NM_016863.4 NP_058559.3 peptidyl-prolyl cis-trans isomerase FKBP1B isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables FK506 binding IDA
IDA: 通过直接分析推断
14592808 MGI
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: 通过直接分析推断
16481613 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14592808 MGI
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
16213210 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within T cell proliferation IMP
IMP: 通过突变表型推断
14605212 MGI
involved in calcium-mediated signaling IMP
IMP: 通过突变表型推断
22087651 MGI
acts upstream of or within insulin secretion IMP
IMP: 通过突变表型推断
18466757 MGI
acts upstream of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
19805579 MGI
involved in negative regulation of heart rate IMP
IMP: 通过突变表型推断
12837242 MGI
acts upstream of or within negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
19805579 MGI
acts upstream of or within neuronal action potential propagation IMP
IMP: 通过突变表型推断
14605212 MGI
acts upstream of or within positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
19805579 MGI
involved in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IMP
IMP: 通过突变表型推断
12837242 MGI
acts upstream of or within regulation of heart rate IMP
IMP: 通过突变表型推断
16672364 MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
IMP: 通过突变表型推断
14592808 MGI
involved in regulation of ryanodine-sensitive calcium-release channel activity IMP
IMP: 通过突变表型推断
12837242 MGI
acts upstream of or within release of sequestered calcium ion into cytosol IMP
IMP: 通过突变表型推断
15024040 MGI
acts upstream of or within response to glucose IMP
IMP: 通过突变表型推断
18466757 MGI
acts upstream of or within smooth muscle contraction IMP
IMP: 通过突变表型推断
14592808 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of calcium channel complex IDA
IDA: 通过直接分析推断
16213210 MGI
located in sarcoplasmic reticulum IDA
IDA: 通过直接分析推断
19578067 MGI
located in sarcoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
14592808 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

peptidyl-prolyl cis-trans isomerase FKBP1B

12.6 kDa FK506-binding protein

12.6 kDa FKBP

FK506-binding protein 12.6

FK506-binding protein 1B

FKBP-12.6

FKBP-1B

PPIase FKBP1B

immunophilin FKBP12.6

rotamase

Fkbp1b 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Fkbp1b Q9Z2I2 Ryr2 Mus musculus E9Q401
Anti Bait CoIP
22939628
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04961 FKBP1B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fkbp1b NCBI NCBI:2281
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