Brd2 - bromodomain containing 2 Gene

中文名称：含溴结构域 2

种属: Mus musculus

同用名: Nat; Rnf3; Frg-1; Fsrg1; Ring3; Fsrg-1; mKIAA4005; D17H6S113E

关于 Brd2

功能概要

预测该基因编码的蛋白可启动赖氨酸-乙酰化组蛋白结合活性；核小体组蛋白结合活性；和蛋白丝氨酸/苏氨酸激酶活性。参与基因表达的调控。在神经管闭合的上游或内部起作用。位于细胞质和细胞核中。以多种结构表达，包括中枢神经系统；未来的大脑；颚;视网膜；和泌尿系统。该基因的人类直系同源物与 B 细胞淋巴瘤有关； B-淋巴细胞白血病/淋巴瘤；青少年肌阵挛性癫痫；和光敏性疾病。与人类 BRD2 同源（含溴结构域 2）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable lysine-acetylated histone binding activity; nucleosomal histone binding activity; and protein serine/threonine kinase activity. Involved in regulation of gene expression. Acts upstream of or within neural tube closure. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; future brain; jaw; retina; and urinary system. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Apr 2022]