2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. SJ46421

SJ46421 是一种基于 (+)-JQ-1 (HY-13030) 的 KLHDC2 PROTAC 蛋白降解剂。SJ46421 能够促进与 KLHDC2 形成相当紧密的三元复合物，IC50 为 7.8 nM。SJ46421 促进 BRD2、BRD3 或 BRD4 的 BD2 结构域多泛素化（粉色：靶蛋白配体 (HY-13030)；黑色：连接子 (HY-20797)；蓝色：E3 连接酶配体 (HY-168536))。

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SJ46421 Chemical Structure

SJ46421 Chemical Structure

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SJ46421 相关抗体

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SJ46421 is a (+)-JQ-1 (HY-13030) based KLHDC2 PROTAC protein degrader. SJ46421 is able to promote a substantially tight ternary complex with KLHDC2 with an IC50 of 7.8 nM. SJ46421 promotes polyubiquitylation of the BD2 domain from BRD2, BRD3, or BRD4 (Pink: ligand for target protein (HY-13030); Black: linker (HY-20797); Blue: E3 ligase ligand (HY-168536))[1].

IC50 & Target[1]

VHL

 

BRD3 BD2

987 nM (Kd)

BRD4 BD2

1020 nM (Kd)

BRD2 BD2

2090 nM (Kd)

分子量

837.41

Formula

C42H41ClN8O5S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SJ46421 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJ46421SJ 46421SJ-46421PROTACsEpigenetic Reader DomainPROTAC KLHDC2 degraderBRD2BRD3BRD4Inhibitorinhibitorinhibit

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产品名称：
SJ46421
目录号：
HY-168634
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