2. Epigenetics
  3. Epigenetic Reader Domain
  4. BRD4 Inhibitor-25

BRD4 Inhibitor-25 是一种 BRD4 抑制剂，对 BRD4 的 BD1 和 BD2 结构域的 IC50 为 0.82 μM，1.94 μM。BRD4 Inhibitor-25 在卵巢癌细胞中诱导凋亡和自噬细胞死亡。 BRD4 Inhibitor-25 可用于癌症、心血管、神经肌肉和炎症性疾病的研究。

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BRD4 Inhibitor-25 Chemical Structure

BRD4 Inhibitor-25 Chemical Structure

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BRD4 Inhibitor-25 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BRD4 Inhibitor-25 is a BRD4 inhibitor with IC50s of 0.82 μM, 1.94 μM for BD1 and BD2 domains of BRD4. BRD4 Inhibitor-25 induces apoptotic and autophagy cell death in ovarian cancer cells. BRD4 Inhibitor-25 can be used in the research of cancers, cardiovascular, neuromuscular and inflammatory disorders.

IC50 & Target[1]

BRD4-BD1

0.82 μM (IC50)

BRD4 (BD2)

1.94 μM (IC50)

BRD4 BD1

0.419 μM (Ki)

BRD4 BD2

0.686 μM (Ki)

BRD2 BD1

15.91 μM (IC50)

BRD2 BD1

7.43 μM (Ki)

体外研究
(In Vitro)

BRD4 Inhibitor-25 (化合物 11a) 抑制 OC 细胞系 (SKOV-3、OVCAR-3、SW626、ES-2 和 A2780) 的细胞增殖[1]。
BRD4 Inhibitor-25 (当用过量的半胱氨酸处理时) 促进中等水平的 NO 释放 (10.587 μM)[1]。
BRD4 Inhibitor-25 (1 和 2 μM，24 小时) 诱导 SKOV-3 细胞凋亡和自噬[1]。
BRD4 Inhibitor-25 (2 μM，24 小时) 抑制自噬体和溶酶体融合，从而阻断 SKOV-3 细胞中的自噬通量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BRD4 Inhibitor-25 相关抗体:

Cell Viability Assay[1]

Cell Line: OC cell lines (SKOV-3, OVCAR-3, SW626, ES-2 and A2780)
Concentration: 0-20 μM approximately
Incubation Time: 24 h
Result: Inhibited cell proliferation with IC50s of 1.38, 2.69, 8.47, 3.44, 3.44 μM respectively.

Western Blot Analysis[1]

Cell Line: SKOV-3 cells
Concentration: 2 μM
Incubation Time: 24 h
Result: Increased cytochrome c and cleaved-caspase 3.
Reduced the anti-apoptosis protein Bcl-2.
Increased the autophagy-related proteins LC3II/I, p62/SQSTM1, and Beclin1.
体内研究
(In Vivo)

BRD4 Inhibitor-25 (化合物 11a，30 mg/kg，腹腔注射) 抑制 SKOV-3 皮下异种移植模型中的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SKOV-3 subcutaneous xenograft model[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Reduced Ki-67, a cell proliferation marker (IHC staining).
分子量

573.62

Formula

C29H27N5O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BRD4 Inhibitor-25 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD4 Inhibitor-25Epigenetic Reader DomainAnticancerautophagosomelysosomeSKOV-3NO releaseInhibitorinhibitorinhibit

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产品名称：
BRD4 Inhibitor-25
目录号：
HY-151972
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