2. Gene
  3. CSNK2A2 - casein kinase 2 alpha 2 Gene

CSNK2A2 - casein kinase 2 alpha 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：酪蛋白激酶 2 α 2

种属: Homo sapiens

同用名: CK2A2; CSNK2A1; CK2alpha'

基因 ID: 1459 | 基因类型: protein coding

关于 CSNK2A2

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,157,907-58,198,106 (from NCBI)

This gene has 8 transcripts (splice variants), 290 orthologues and 2 paralogues. Broad expression in testis (RPKM 55.0), skin (RPKM 19.3) and 24 other tissues.

功能概要

该基因编码蛋白激酶酪蛋白激酶 2 (CK2) 的 alpha' 或 alpha 2 催化亚基。酪蛋白激酶 2 是一种丝氨酸/苏氨酸蛋白激酶，可使酸性蛋白 (如酪蛋白) 磷酸化。它参与各种细胞过程，包括细胞周期控制、细胞凋亡和昼夜节律。这种异四聚体激酶包括两个催化亚基 (α 或α') 和两个调节性β 亚基。在 20 号染色体上发现了编码 alpha 或 alpha 1 亚基 (CSNK2A1，基因 ID：1457) 的密切相关基因旁系同源基因。该基因 (alpha 2) 的内含子变异可能与南亚人群的白细胞端粒长度有关。在 11 号染色体上发现了一个相关的转录假基因。[RefSeq 提供，2017 年 8 月]

This gene encodes the alpha', or alpha 2, catalytic subunit of the protein kinase Enzyme, Casein Kinase 2 (CK2). Casein Kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, Apoptosis, and circadian rhythms. This heterotetrameric kinase includes two catalytic subunits, either alpha or alpha', and two regulatory beta subunits. The closely related gene paralog encoding the alpha, or alpha 1 subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An intronic variant in this gene (alpha 2) may be associated with leukocyte telomere length in a South Asian population. A related transcribed pseudogene is found on chromosome 11. [provided by RefSeq, Aug 2017]

CSNK2A2 基因产物(1)

mRNA Protein Name
NM_001896.4 NP_001887.1 casein kinase II subunit alpha'
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10094392 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
20545769 GOA
enables protein serine/threonine kinase activity IGI
IGI: 通过遗传相互作用推断
28031292 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in double-strand break repair IDA
IDA: 通过直接分析推断
22325354 GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
IGI: 通过遗传相互作用推断
28031292 GOA
involved in regulation of chromosome separation IMP
IMP: 通过突变表型推断
11704824 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of PcG protein complex IDA
IDA: 通过直接分析推断
21282530 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21282530 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CSNK2A2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (40 - 325)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
蛋白主名 其他名称

casein kinase II subunit alpha'

CK II alpha'

重组 CSNK2A2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76296 CK2 alpha/CSNK2A2 Protein, Human (sf9) P19784 (N-G&P, M1-R350) ≥95%
HY-P76297 CK2 alpha/CSNK2A2 Protein, Human (sf9, His-GST) P19784 (M1-R350) ≥95%

关联疾病

疾病名称 别名
Theileriasis

Theileriosis

Infection By Theileria
Spermatogenic Failure 6

Globozoospermia

SPGF6

Round-Headed Spermatozoa

Acrosome Malformation Of Spermatozoa

Spermatogenic Failure 9

Spermatozoa, Round-Headed

Globozoospermia, Complete

Globozoospermia, Total

Mae Infertility Due To Round-Headed Spermatozoa

Male Infertility Due To Globozoospermia

Male Infertility Due To Round-Headed Spermatozoa

Round-Headed Sperm Syndrome

Spgf9

Teratozoospermia
Okur-Chung Neurodevelopmental Syndrome

OCNDS

Csnk2a1-Related Neurodevelopmental Syndrome
Spermatogenic Failure 9

Male Infertility Due To Globozoospermia

SPGF9

Male Infertility Due To Round-Headed Spermatozoa

Globozoospermia, Complete

Globozoospermia, Total

Globozoospermia

Globozoospermia Syndrome

Round-Headed Sperm Syndrome

Globozoospermia Complete

Globozoospermia Total
Neonatal Leukemia
Connective Tissue Disease

Connective Tissue Diseases

Connective Tissue Disorder

Abnormality Of Connective Tissue

Disorder Of Connective Tissue

Connective Tissue Disorders
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-168595 CSNK2-IN-2 Inhibitor / 否
HY-RS03252 CSNK2A2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-163182 CSNK2A-IN-2 Inhibitor / 否
HY-163783 CSNK2-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CSNK2A2 RGD RGD:1306882
Mus musculus CSNK2A2 MGD MGI:88547
Canis familiaris CSNK2A2 VGNC VGNC:39670
Macaca mulatta CSNK2A2 VGNC VGNC:71524
Bos taurus CSNK2A2 VGNC VGNC:27769
Felis catus CSNK2A2 VGNC VGNC:61226
Others CSNK2A2 NCBI
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