2. Gene
  3. CSPG4 - chondroitin sulfate proteoglycan 4 Gene

CSPG4 - chondroitin sulfate proteoglycan 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：硫酸软骨素蛋白多糖 4

种属: Homo sapiens

同用名: NG2; MCSP; MCSPG; MSK16; CSPG4A; HMW-MAA; MEL-CSPG

基因 ID: 1464 | 基因类型: protein coding

关于 CSPG4

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,674,322-75,713,466 (from NCBI)

This gene has 1 transcript (splice variant) and 193 orthologues. Broad expression in fat (RPKM 18.8), placenta (RPKM 10.9) and 19 other tissues.

功能概要

人黑色素瘤相关的硫酸软骨素蛋白聚糖在内皮基底膜上黑色素瘤细胞扩散的早期事件期间，在稳定细胞-基质相互作用中发挥作用。 CSPG4 代表由人恶性黑色素瘤细胞表达的完整膜硫酸软骨素蛋白多糖。[RefSeq 提供，2008 年 7 月]

A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]

CSPG4 基因产物(1)

mRNA Protein Name
NM_001897.5 NP_001888.2 chondroitin sulfate proteoglycan 4 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
10587647 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
10587647 GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
10587647 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CSPG4 蛋白结构

Laminin_G_1

Laminin_G_1: Laminin G domain (55 - 180)

Laminin_G_2

Laminin_G_2: Laminin G domain (231 - 363)

  • 0
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  • 2000
  • 2322 a.a.
蛋白主名 其他名称

chondroitin sulfate proteoglycan 4

chondroitin sulfate proteoglycan 4 (melanoma-associated)

CSPG4 抗体

目录号 产品名 应用 反应物种
HY-P83476 NG2 Antibody (YA3221) WB, IHC-P, FC Human

关联疾病

疾病名称 别名
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Demyelinating Disease

Demyelinating Diseases

Demyelinating Disorder
Chordoma

CHDM

Notochordoma

Notochordal Sarcoma

Chordoma, Susceptibility To

Chordocarcinoma

Chordoepithelioma
Acral Lentiginous Melanoma

Acral Lentiginous Melanoma, Malignant

Malignant Acral Lentiginous Melanoma

Alm

Acral Lentiginous Malignant Melanoma Of Skin

Palmar/Plantar Melanoma

Subungual Melanoma

Acral Lentiginous Malignant Melanoma
Ullrich Congenital Muscular Dystrophy 1

Ullrich Congenital Muscular Dystrophy

Ullrich Disease

Ucmd

Ullrich Scleroatonic Muscular Dystrophy

Scleroatonic Muscular Dystrophy

UCMD1

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 22

Lgmdr22

Muscular Dystrophy, Scleroatonic

Late Onset Scleroatonic Familial Myopathy

Congenital Muscular Dystrophy, Ullrich Type
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03254 CSPG4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CSPG4 RGD RGD:619942
Mus musculus CSPG4 MGD MGI:2153093
Bos taurus CSPG4 VGNC VGNC:57158
Felis catus CSPG4 VGNC VGNC:61227
Macaca mulatta CSPG4 VGNC VGNC:71525
Canis familiaris CSPG4 VGNC VGNC:59107
Macaca fascicularis CSPG4 NCBI
Others CSPG4 NCBI
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