2. Gene
  3. Slc6a9 - solute carrier family 6 (neurotransmitter transporter, glycine), member 9 Gene

Slc6a9 - solute carrier family 6 (neurotransmitter transporter, glycine), member 9 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 6 (神经递质转运蛋白，甘氨酸) ，成员 9

种属: Mus musculus

同用名: Glyt1; Glyt-1

基因 ID: 14664 | 基因类型: protein coding

关于 Slc6a9

Chromosome 4: 117,691,703-117,732,395 forward strand.GRCm39:CM000997.3

This gene has 12 transcripts (splice variants), 206 orthologues, 20 paralogues and is associated with 25 phenotypes. Ubiquitous expression in liver E14.5 (RPKM 33.4), cerebellum adult (RPKM 3.9) and 27 other tissues.

功能概要

该基因编码的蛋白可启动甘氨酸跨膜转运蛋白活性。参与甘氨酸跨质膜输入；神经递质摄取；和细胞生物合成过程的正向调节。作用于甘氨酸分泌、神经传递的上游或内部。位于质膜。以多种结构表达，包括中枢神经系统；眼睛;泌尿生殖系统；直觉;以及肝脏和胆道系统。用于研究甘氨酸脑病。与人类 SLC6A9（溶质载体家族 6 成员 9）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables glycine transmembrane transporter activity. Involved in glycine import across plasma membrane; neurotransmitter uptake; and positive regulation of cellular biosynthetic process. Acts upstream of or within glycine secretion, neurotransmission. Located in plasma membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and liver and biliary system. Used to study glycine encephalopathy. Orthologous to human SLC6A9 (solute carrier family 6 member 9). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a9 基因产物(4)

mRNA Protein Name
NM_001355175.2 NP_001342104.1 sodium- and chloride-dependent glycine transporter 1 isoform 2
NM_001369017.1 NP_001355946.1 sodium- and chloride-dependent glycine transporter 1 isoform 3 precursor
NM_001369016.1 NP_001355945.1 sodium- and chloride-dependent glycine transporter 1 isoform 1
NM_008135.4 NP_032161.2 sodium- and chloride-dependent glycine transporter 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glycine transmembrane transporter activity IDA
IDA: 通过直接分析推断
1618338 MGI
enables glycine transmembrane transporter activity IMP
IMP: 通过突变表型推断
15159536 MGI
enables glycine:sodium symporter activity IDA
IDA: 通过直接分析推断
1618338 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in glycine import across plasma membrane IMP
IMP: 通过突变表型推断
28495915 MGI
acts upstream of or within glycine secretion, neurotransmission IMP
IMP: 通过突变表型推断
22988142 MGI
acts upstream of or within glycine transport IDA
IDA: 通过直接分析推断
1618338 MGI
involved in glycine transport IMP
IMP: 通过突变表型推断
14622582 MGI
acts upstream of negative regulation of NMDA glutamate receptor activity IMP
IMP: 通过突变表型推断
15159536 MGI
involved in neurotransmitter uptake IDA
IDA: 通过直接分析推断
1618338 MGI
involved in neurotransmitter uptake IMP
IMP: 通过突变表型推断
1618338 MGI
involved in positive regulation of heme biosynthetic process IMP
IMP: 通过突变表型推断
28495915 MGI
involved in positive regulation of hemoglobin biosynthetic process IMP
IMP: 通过突变表型推断
28495915 MGI
involved in regulation of synaptic transmission, glycinergic IMP
IMP: 通过突变表型推断
14622582 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
17724084 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Slc6a9 蛋白结构

SLC6sbd_GlyT1

SLC6sbd_GlyT1: cd11498 (10 - 593)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 633 a.a.
蛋白主名 其他名称

sodium- and chloride-dependent glycine transporter 1

glycine transporter 1

solute carrier family 6 member 9

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13320 SLC6A9 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13321 Slc6a9 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13322 Slc6a9 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc6a9 NCBI NCBI:6536
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