SLC25A10 - solute carrier family 25 member 10 Gene

中文名称：溶质载体家族 25 成员 10

种属: Homo sapiens

同用名: DIC; MTDPS19

基因 ID: 1468 | 基因类型: protein coding

关于 SLC25A10

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,712,284-81,721,012 (from NCBI)

This gene has 8 transcripts (splice variants), 237 orthologues, 49 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 33.1), liver (RPKM 15.3) and 20 other tissues.

功能概要

该基因编码一个蛋白质家族的成员，该蛋白质家族可将小代谢物转移到线粒体膜上。编码的蛋白质将苹果酸和琥珀酸等二羧酸盐交换为磷酸盐、硫酸盐和其他小分子，从而为包括三羧酸循环和脂肪酸合成在内的代谢过程提供底物。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 8 月]

This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

SLC25A10 基因产物(3)

mRNA	Protein	Name
NM_001270888.2	NP_001257817.1	mitochondrial dicarboxylate carrier isoform 1
NM_001270953.2	NP_001257882.1	mitochondrial dicarboxylate carrier isoform 3
NM_012140.5	NP_036272.2	mitochondrial dicarboxylate carrier isoform 2

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables dicarboxylic acid transmembrane transporter activity	EXP EXP: 通过实验结果推断	29211846	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19060904	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC25A10 蛋白结构

Mito_carr

0
100
200
287 a.a.

蛋白主名

其他名称

mitochondrial dicarboxylate carrier

dicarboxylate ion carrier

SLC25A10 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SLC25A10	Q9UBX3	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	SLC25A10	Q9UBX3	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	SLC25A10	Q9UBX3	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	SLC25A10	Q9UBX3	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	SLC25A10	Q9UBX3	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	25416956
Intra	SLC25A10	Q9UBX3	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Array	25416956
Intra	SLC25A10	Q9UBX3	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
Intra	SLC25A10	Q9UBX3	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
Intra	SLC25A10	Q9UBX3	MDFI	Homo sapiens	Q99750	Y2H	21516116
Intra	SLC25A10	Q9UBX3	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
Intra	SLC25A10	Q9UBX3	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	SLC25A10	Q9UBX3	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	SLC25A10	Q9UBX3	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mitochondrial Dna Depletion Syndrome 19

MTDPS19

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Mitochondrial Dna Depletion Syndrome

Mtdna Depletion Syndrome

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression	Early Infantile Epileptic Encephalopathy With Suppression Bursts
Eiee	Early Infantile Epileptic Encephalopathy With Suppression-Bursts
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13090	SLC25A10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SLC25A10	VGNC	VGNC:107277
Felis catus	SLC25A10	VGNC	VGNC:99452
Mus musculus	SLC25A10	MGD	MGI:1353497
Rattus norvegicus	SLC25A10	RGD	RGD:621430

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC25A10 - solute carrier family 25 member 10 Gene

关于 SLC25A10

功能概要

SLC25A10 基因产物(3)

SLC25A10 蛋白结构

SLC25A10 蛋白互作信息

关联疾病

直系同源

热门区域

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SLC25A10 - solute carrier family 25 member 10 Gene

关于 SLC25A10

功能概要

SLC25A10 基因产物(3)

SLC25A10 蛋白结构

SLC25A10 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

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T

X

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