2. Gene
  3. Gpc3 - glypican 3 Gene

Gpc3 - glypican 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: OCI-5

基因 ID: 14734 | 基因类型: protein coding

关于 Gpc3

功能概要

Predicted to enable peptidyl-dipeptidase inhibitor activity. Involved in mesenchymal cell proliferation involved in ureteric bud development. Acts upstream of or within several processes, including animal organ development; positive regulation of transport; and regulation of signal transduction. Located in lysosome and plasma membrane. Is anchored component of plasma membrane. Is expressed in several structures, including branchial arch; future brain; lower jaw; reproductive system; and urinary system. Used to study Simpson-Golabi-Behmel syndrome type 1. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1; hepatocellular carcinoma; and nephroblastoma. Orthologous to human GPC3 (glypican 3). [provided by Alliance of Genome Resources, Apr 2022]

Gpc3 基因产物(1)

mRNA Protein Name
NM_016697.3 NP_057906.2 glypican-3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18343214 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of Wnt signaling pathway, planar cell polarity pathway IMP
IMP: 通过突变表型推断
15537637 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
9853964 MGI
acts upstream of or within anterior/posterior axis specification IGI
IGI: 通过遗传相互作用推断
10964473 MGI
acts upstream of or within body morphogenesis IMP
IMP: 通过突变表型推断
18477453 MGI
acts upstream of or within bone mineralization IMP
IMP: 通过突变表型推断
15936336 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IGI
IGI: 通过遗传相互作用推断
15925496 MGI
acts upstream of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
15537637 MGI
acts upstream of or within cell proliferation involved in kidney development IMP
IMP: 通过突变表型推断
11180950 MGI
acts upstream of or within cell proliferation involved in metanephros development IMP
IMP: 通过突变表型推断
10402475 MGI
acts upstream of or within coronary vasculature development IMP
IMP: 通过突变表型推断
19733558 MGI
acts upstream of or within embryonic hindlimb morphogenesis IGI
IGI: 通过遗传相互作用推断
10964473 MGI
acts upstream of epithelial cell proliferation IMP
IMP: 通过突变表型推断
10402475 MGI
acts upstream of or within epithelial cell proliferation IMP
IMP: 通过突变表型推断
10402475 MGI
acts upstream of growth IMP
IMP: 通过突变表型推断
15537637 MGI
acts upstream of or within kidney development IMP
IMP: 通过突变表型推断
10402475 MGI
acts upstream of or within lung development IMP
IMP: 通过突变表型推断
10402475 MGI
involved in mesenchymal cell proliferation involved in ureteric bud development IMP
IMP: 通过突变表型推断
15925496 MGI
acts upstream of or within mesonephric duct morphogenesis IMP
IMP: 通过突变表型推断
11180950 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
15537637 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
15925496 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
10402475 MGI
acts upstream of or within negative regulation of growth IMP
IMP: 通过突变表型推断
11846487 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
19590577 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IMP
IMP: 通过突变表型推断
18477453 MGI
acts upstream of or within osteoclast differentiation IMP
IMP: 通过突变表型推断
15936336 MGI
acts upstream of or within positive regulation of BMP signaling pathway IMP
IMP: 通过突变表型推断
15925496 MGI
acts upstream of or within positive regulation of D-glucose import IDA
IDA: 通过直接分析推断
18343214 MGI
acts upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway IMP
IMP: 通过突变表型推断
15537637 MGI
acts upstream of or within positive regulation of endocytosis IDA
IDA: 通过直接分析推断
18477453 MGI
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: 通过直接分析推断
18477453 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IMP
IMP: 通过突变表型推断
19733558 MGI
acts upstream of or within regulation of growth IGI
IGI: 通过遗传相互作用推断
19590577 MGI
acts upstream of or within regulation of growth IMP
IMP: 通过突变表型推断
10402475 MGI
acts upstream of or within response to bacterium IEP
IEP: 通过表达模式推断
23012479 MGI
acts upstream of smoothened signaling pathway IMP
IMP: 通过突变表型推断
19733558 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in lysosome IDA
IDA: 通过直接分析推断
18477453 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
18343214 MGI
located in plasma membrane IMP
IMP: 通过突变表型推断
18477453 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

glypican-3

重组 Gpc3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70872 Glypican-3/GPC3 Protein, Mouse (HEK293, His) Q8CFZ4 (Q25-M557) ≥95%
HY-P73078 Glypican-3/GPC3 Protein, Mouse (sf9, His) Q8CFZ4 (Q25-P558) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99013 Codrituzumab Inhibitor 95.70% Phase 2
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153360 MC-GGFG-AM-(10Me-11F-Camptothecin) Inhibitor 98.06% 否
HY-RS05628 GPC3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990840 Anti-GPC3 Antibody (YP7) Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gpc3 NCBI NCBI:2719
Macaca fascicularis Gpc3 NCBI NCBI:102137748
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