S1pr2 - sphingosine-1-phosphate receptor 2 Gene

中文名称：1-磷酸鞘氨醇受体 2

种属: Mus musculus

同用名: Edg5; H218; LPb2; S1P2; Gpcr13; 1100001A16Rik

关于 S1pr2

功能概要

预计该基因编码的蛋白可启动 G 蛋白偶联受体活性和信号受体结合活性。参与肽基-苏氨酸磷酸化和鞘氨醇-1-磷酸受体信号通路的正调控。在兴奋性突触后电位的负调节上游或负调节内起作用。预测位于膜中。预计是膜的组成部分。预计在细胞质和质膜中有活性。以多种结构表达，包括消化系统；脑;鳃弓;泌尿生殖系统；和感觉器官。用于研究常染色体隐性遗传性非综合征性耳聋 68 和非霍奇金淋巴瘤。该基因的人类直向同源基因与常染色体隐性非综合征性耳聋 68 相关。与人类 S1PR2（1-磷酸鞘氨醇受体 2）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable G protein-coupled receptor activity and signaling receptor binding activity. Involved in positive regulation of peptidyl-threonine phosphorylation and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within negative regulation of excitatory postsynaptic potential. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness 68 and non-Hodgkin lymphoma. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 68. Orthologous to human S1PR2 (sphingosine-1-phosphate receptor 2). [provided by Alliance of Genome Resources, Apr 2022]