2. Gene
  3. S1PR2 - sphingosine-1-phosphate receptor 2 Gene

S1PR2 - sphingosine-1-phosphate receptor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：1-磷酸鞘氨醇受体 2

种属: Homo sapiens

同用名: EDG5; H218; LPB2; S1P2; AGR16; EDG-5; DFNB68; Gpcr13

基因 ID: 9294 | 基因类型: protein coding

关于 S1PR2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,221,433-10,231,331 (from NCBI)

This gene has 1 transcript (splice variant), 192 orthologues, 18 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 10.4), lymph node (RPKM 5.1) and 22 other tissues.

功能概要

该基因编码 G 蛋白偶联受体的一个成员，以及 EDG 蛋白家族。编码的蛋白质是鞘氨醇 1-磷酸的受体，参与细胞增殖、存活和转录激活。该基因的缺陷与先天性深度耳聋有关。[RefSeq 提供，2016 年 3 月]

This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]

S1PR2 基因产物(1)

mRNA Protein Name
NM_004230.4 NP_004221.3 sphingosine 1-phosphate receptor 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled peptide receptor activity IPI
IPI: 通过物理相互作用推断
29453251 GOA
enables G protein-coupled receptor binding IPI
IPI: 通过物理相互作用推断
24851274 GOA
enables integrin binding IPI
IPI: 通过物理相互作用推断
24851274 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24453941 GOA
enables sphingosine-1-phosphate receptor activity IDA
IDA: 通过直接分析推断
29453251 GOA
enables sphingosine-1-phosphate receptor activity IMP
IMP: 通过突变表型推断
23106337 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
29453251 GOA
involved in actin cytoskeleton organization IMP
IMP: 通过突变表型推断
23106337 GOA
involved in filopodium assembly IMP
IMP: 通过突变表型推断
23106337 GOA
involved in positive regulation of establishment of endothelial barrier IMP
IMP: 通过突变表型推断
24851274 GOA
involved in positive regulation of peptidyl-threonine phosphorylation IMP
IMP: 通过突变表型推断
23106337 GOA
involved in sphingosine-1-phosphate receptor signaling pathway IMP
IMP: 通过突变表型推断
23106337 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
24851274 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

S1PR2 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (50 - 288)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
蛋白主名 其他名称

sphingosine 1-phosphate receptor 2

CTD-2369P2.2

S1P receptor 2

S1P receptor EDG5

S1P receptor Edg-5

deafness, autosomal recessive 68

endothelial differentiation G-protein coupled receptor 5

endothelial differentiation, sphingolipid G-protein-coupled receptor, 5

sphingosine 1-phosphate receptor Edg-5

关联疾病

疾病名称 别名
Pulmonary Edema
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Sensorineural Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency
Ezb Diffuse Large B-Cell Lymphoma

Ezb Dlbcl

Doid:0081065
Deafness, Autosomal Recessive 68

DFNB68

Autosomal Recessive Nonsyndromic Deafness 68

Autosomal Recessive Deafness 68

Deafness, Autosomal Recessive, 68

Deafness, Autosomal Recessive, Type 68
Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb

Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb

Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb

Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb

Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12355 Siponimod Agonist 99.95% 否
HY-12355A Siponimod hemifumarate Agonist / 否
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-139310 GLPG2938 Antagonist 99.93% 否
HY-111253 CYM-5478 Agonist 99.90% 否
HY-113934 L-threo Lysosphingomyelin (d18:1) Agonist ≥98.0% 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus S1PR2 RGD RGD:68334
Felis catus S1PR2 VGNC VGNC:64846
Mus musculus S1PR2 MGD MGI:99569
Macaca mulatta S1PR2 VGNC VGNC:77144
Canis familiaris S1PR2 VGNC VGNC:108257
Bos taurus S1PR2 VGNC VGNC:34253
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