1. Gene
  2. CSTF1 - cleavage stimulation factor subunit 1 Gene

CSTF1 - cleavage stimulation factor subunit 1 Gene

中文名称:裂解刺激因子亚基 1

种属: Homo sapiens

同用名: CstF-50; CstFp50

基因 ID: 1477 | 基因类型: protein coding

关于 CSTF1

Cytogenetic location: 20q13.2-q13.31 Genomic coordinates (GRCh38): 20:56,392,379-56,406,362 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 12.7), lymph node (RPKM 8.5) and 25 other tissues.

功能概要

该基因编码三个亚基之一,这些亚基结合形成切割刺激因子 (CSTF) 。 CSTF 参与前体 mRNA 的聚腺苷酸化和 3' 末端切割。与哺乳动物 G 蛋白 β 亚基类似,该蛋白包含转导蛋白样重复序列。已针对该基因发现了几种具有不同 5' UTR 但编码相同蛋白质的转录物变体。[RefSeq 提供,2008 年 7 月]

This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

CSTF1 基因产物(3)

mRNA Protein Name
NM_001033521.2 NP_001028693.1 cleavage stimulation factor subunit 1
NM_001033522.2 NP_001028694.1 cleavage stimulation factor subunit 1
NM_001324.3 NP_001315.1 cleavage stimulation factor subunit 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10477523 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CSTF1 蛋白结构

WD40

WD40: WD domain, G-beta repeat (105 - 134)

WD40

WD40: WD domain, G-beta repeat (166 - 201)

WD40

WD40: WD domain, G-beta repeat (261 - 290)

WD40

WD40: WD domain, G-beta repeat (308 - 334)

WD40

WD40: WD domain, G-beta repeat (395 - 424)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
蛋白主名 其他名称

cleavage stimulation factor subunit 1

CF-1 50 kDa subunit

CSTF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CSTF1 Q05048 BARD1 Homo sapiens Q99728
Y2H
10477523
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CSTF1 VGNC VGNC:71535
Felis catus CSTF1 VGNC VGNC:61239
Bos taurus CSTF1 VGNC VGNC:27780
Rattus norvegicus CSTF1 RGD RGD:1309267
Mus musculus CSTF1 MGD MGI:1914587
Canis familiaris CSTF1 VGNC VGNC:39682