1. Gene
  2. DACT3 - dishevelled binding antagonist of beta catenin 3 Gene

DACT3 - dishevelled binding antagonist of beta catenin 3 Gene

中文名称:连环蛋白 3 的散乱结合拮抗因子

种属: Homo sapiens

同用名: RRR1; DAPPER3

基因 ID: 147906 | 基因类型: protein coding

关于 DACT3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,647,551-46,661,182 (from NCBI)

This gene has 3 transcripts (splice variants), 228 orthologues and 2 paralogues. Broad expression in brain (RPKM 11.1), endometrium (RPKM 7.4) and 17 other tissues.

功能概要

预测启用 delta-连环蛋白结合活性;蛋白激酶 A 结合活性;和蛋白激酶 C 结合活性。参与经典 Wnt 信号通路的负调控和细胞生长的负调控。预计在细胞质中有活性。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable delta-catenin binding activity; protein kinase A binding activity; and protein kinase C binding activity. Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of cell growth. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DACT3 基因产物(2)

mRNA Protein Name
NM_001301046.2 NP_001287975.1 dapper homolog 3 isoform 2
NM_145056.3 NP_659493.2 dapper homolog 3 isoform 1
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of Wnt signaling pathway IDA
IDA: 通过直接分析推断
18538736 GOA
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
18538736 GOA
involved in negative regulation of cell growth IDA
IDA: 通过直接分析推断
18538736 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DACT3 蛋白结构

Dapper

Dapper: Dapper (20 - 129)

Dapper

Dapper: Dapper (545 - 629)

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  • 629 a.a.
蛋白主名 其他名称

dapper homolog 3

antagonist of beta-catenin Dapper homolog 3

直系同源

种属 基因名 来源 基因 ID
Bos taurus DACT3 VGNC VGNC:27869
Rattus norvegicus DACT3 RGD RGD:1563892
Mus musculus DACT3 MGD MGI:3654828
Canis familiaris DACT3 VGNC VGNC:53696