Nr3c1 - nuclear receptor subfamily 3, group C, member 1 Gene

中文名称：核受体亚家族 3 ，C 组，成员 1

种属: Mus musculus

同用名: GR; Grl1; Grl-1

关于 Nr3c1

功能概要

该基因编码的蛋白可启动多种功能，包括糖皮质激素受体活性；相同的蛋白质结合活性；和蛋白激酶结合活性。参与 RNA 聚合酶 II 对 pri-miRNA 转录的正调控。作用于多个过程的上游或内部，包括腺体发育；糖皮质激素受体信号通路；和调节细胞生物合成过程。位于胞质溶胶中；膜;和核。以多种结构表达，包括消化系统；中枢神经系统;泌尿生殖系统；肺;和感觉器官。用于研究原发性醛固酮增多症。该基因的人类直系同源物与多种疾病有关，包括神经性厌食症；肺部疾病（多发）；严重抑郁症;肥胖;和肾细胞癌。与人类 NR3C1（核受体亚家族 3 C 组成员 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including Glucocorticoid Receptor activity; identical protein binding activity; and protein kinase binding activity. Involved in positive regulation of pri-miRNA transcription by RNA polymerase II. Acts upstream of or within several processes, including gland development; Glucocorticoid Receptor signaling pathway; and regulation of cellular biosynthetic process. Located in cytosol; membrane; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and sensory organ. Used to study primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1). [provided by Alliance of Genome Resources, Apr 2022]