Hspa5 - heat shock protein 5 Gene

中文名称：热休克蛋白5

种属: Mus musculus

同用名: Bip; Sez7; mBiP; Grp78; SEZ-7; Hsce70; baffled; D2Wsu17e; D2Wsu141e

关于 Hspa5

功能概要

该基因编码的蛋白可启动错误折叠的蛋白质结合活性和核糖体结合活性。参与多个过程，包括 IRE1 介导的未折叠蛋白反应；小脑发育；和蛋白质泛素化的正调控。作用于多个过程的上游或内部，包括细胞对 interleukin-4 的反应；转化生长因子β受体信号通路的负调控；和毒素运输。位于多个细胞成分中，包括细胞表面；内质网；和内质网-高尔基中间室。内质网伴侣复合体的一部分。以多种结构表达，包括消化系统；脑;眼睛;泌尿生殖系统；和肌肉骨骼系统。该基因的人类直系同源物与多巴胺 β-羟化酶缺乏症有关。与人类 HSPA5（热休克蛋白家族 A (HSP70) 成员 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables misfolded protein binding activity and ribosome binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; cerebellum development; and positive regulation of protein ubiquitination. Acts upstream of or within several processes, including cellular response to interleukin-4; negative regulation of transforming growth factor beta receptor signaling pathway; and toxin transport. Located in several cellular components, including cell surface; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and musculoskeletal system. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (HSP70) member 5). [provided by Alliance of Genome Resources, Apr 2022]